caa a22 4500 477036295 CHVBK 20180405111306.0 cr unu---uuuuu 170330e19961001xx s 000 0 eng 10.1007/s002689900145 doi (NATIONALLICENCE)springer-10.1007/s002689900145 Low-Molecular-Weight Heparins and Daflon for Prevention of Postoperative Thromboembolism [Elektronische Daten] [Evangelos C. Tsimoyiannis, Grigorios Floras, Nikolaos Antoniou, Nikolaos Papanikolaou, Philipos Siakas, Andreas Tassis] Abstract. The efficacy of low-molecular-weight heparins (LMWH) alone versus a combination of Daflon 500 mg with LMWH in preventing postoperative symptomatic thromboembolism was investigated. A total of 1372 patients aged 40 years or older undergoing major abdominal, pelvic, or abdominal wall surgery were randomized into four groups. Group A (: n = 591) received enoxoparin 20 mg or fraxiparin 0.3 ml. Group B ( n = 595) received the regimens of group A plus Daflon 500 mg. Group C ( n = 93) received enoxoparin 40 mg or fraxiparin 0.6 ml. Group D ( n = 93) received the regimens of group C plus Daflon 500 mg. Each LMWH was given subcutaneously once a day during the hospitalization and continued in groups C and D for 15 days after discharge (high risk patients). Daflon 500 mg was given as two tablets every 8 hours during the day before surgery, two tablets 6 hours before surgery, and two tablets once a day on postoperative days 4 to 15. Daily clinical examination was performed; and phlebography or perfusion lung scanning (or both) were used in symptomatic patients to confirm deep vein thrombosis (DVT) or pulmonary embolism (PE). The wound was examined on a daily basis for hematomas. The diagnosis of PE was established in two patients of group A and in three patients of group C; symptomatic DVT was established in one patient in group A and three patients of group C. Neither DVT nor PE were established in Daflon 500 mg groups. These data suggest that the combination of Daflon 500 mg and LMWH is more effective than LMWH alone for preventing symptomatic thromboembolism. 1996 by the Société Internationale de Chir, ugie Tsimoyiannis Evangelos C. Department of Surgery, G. Hatzikosta General Hospital, Makriyianni Avenue, Ioannina, 45001 Greece, GR aut Floras Grigorios Department of Surgery, G. Hatzikosta General Hospital, Makriyianni Avenue, Ioannina, 45001 Greece, GR aut Antoniou Nikolaos Department of Gynecology-Obstetrics, G. Hatzikosta General Hospital, Makriyianni Avenue, Ioannina, 45001 Greece, GR aut Papanikolaou Nikolaos Department of Gynecology-Obstetrics, G. Hatzikosta General Hospital, Makriyianni Avenue, Ioannina, 45001 Greece, GR aut Siakas Philipos Department of Surgery, G. Hatzikosta General Hospital, Makriyianni Avenue, Ioannina, 45001 Greece, GR aut Tassis Andreas Department of Surgery, G. Hatzikosta General Hospital, Makriyianni Avenue, Ioannina, 45001 Greece, GR aut https://doi.org/10.1007/s002689900145 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689900145 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tsimoyiannis Evangelos C. Department of Surgery, G. Hatzikosta General Hospital, Makriyianni Avenue, Ioannina, 45001 Greece, GR aut NATIONALLICENCE 700 1- Floras Grigorios Department of Surgery, G. Hatzikosta General Hospital, Makriyianni Avenue, Ioannina, 45001 Greece, GR aut NATIONALLICENCE 700 1- Antoniou Nikolaos Department of Gynecology-Obstetrics, G. Hatzikosta General Hospital, Makriyianni Avenue, Ioannina, 45001 Greece, GR aut NATIONALLICENCE 700 1- Papanikolaou Nikolaos Department of Gynecology-Obstetrics, G. Hatzikosta General Hospital, Makriyianni Avenue, Ioannina, 45001 Greece, GR aut NATIONALLICENCE 700 1- Siakas Philipos Department of Surgery, G. Hatzikosta General Hospital, Makriyianni Avenue, Ioannina, 45001 Greece, GR aut NATIONALLICENCE 700 1- Tassis Andreas Department of Surgery, G. Hatzikosta General Hospital, Makriyianni Avenue, Ioannina, 45001 Greece, GR aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer