caa a22 4500 477036368 CHVBK 20180405111306.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/s002689900082 doi (NATIONALLICENCE)springer-10.1007/s002689900082 Acute Phase is the Only Significantly Reduced Component of the Injury Response after Laparoscopic Cholecystectomy [Elektronische Daten] [Eduardo Targarona, María José Pons, Carmen Balagué, Juan José Espert, Antonio Moral, Joaquín Martínez, Juan Gaya, Xavier Filella, Francisca Rivera, Antonio Ballesta, Manuel Trías] The objective demonstration of improved postoperative recovery suggests that the surgical injury response induced by the laparoscopic approach is less intense than that after open surgery. Twenty-five patients diagnosed as having noncomplicated gallstones were studied prospectively. They were operated by laparoscopy (group I, n = 12) or open surgery (group II, n = 13). Analgesia requirements (p < 0.026) and postoperative stay (p < 0.001) were significantly less in group I. Cholecystectomy performed by either technical options induced a significant increase over basal values of glucose, lactate, white blood cell count, prolactin, ACTH, cortisol, interleukin 6, C-reactive protein, and PCO2. Both surgical procedures induced a significant reduction of total proteins, albumin, prealbumin, free fatty acids hemoglobin, hematocrit, and pH. There were no differences between the levels of growth hormone, insulin, glucagon, or PO2 during any of the periods studied. Comparison of the results of the two cholecystectomy techniques showed that laparoscopic cholecystectomy induced a significantly less intense acute-phase response (area under the curve) of interleukin 6 (17 ± 17 versus 47 ± 26 pg/ml × hr × 102; p < 0.003), C-reactive protein (16 ± 12 versus 35 ± 16 mg/dl × hr × 10; p < 0.004), and prealbumin (16 ± 2.7 versus 13.8 ± 2.3 mg/dl × hr × 102; p < 0.05). The surgical injury response after laparoscopic cholecystectomy is similar to that after open cholecystectomy, but the acute-phase response component is less intense. This finding may be a consequence of the reduced size of the operative wound with laparoscopic cholecystectomy. Société Internationale de Chirugie, 1996 Targarona Eduardo Division of Surgery, Hospital Clinic, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut Pons María José Division of Surgery, Hospital Clinic, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut Balagué Carmen Division of Surgery, Hospital Clinic, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut Espert Juan José Division of Surgery, Hospital Clinic, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut Moral Antonio Division of Surgery, Hospital Clinic, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut Martínez Joaquín Division of Surgery, Hospital Clinic, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut Gaya Juan Laboratory of Hormonal Biochemistry, Hospital Clinic, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut Filella Xavier Laboratory of Biochemistry, Hospital Clinic, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut Rivera Francisca Laboratory of Biochemistry, Hospital Clinic, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut Ballesta Antonio Laboratory of Biochemistry, Hospital Clinic, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut Trías Manuel Division of Surgery, Hospital Clinic, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut World Journal of Surgery Springer-Verlag 20/5(1996-06-01), 528-534 0364-2313 20:5<528 1996 20 268 https://doi.org/10.1007/s002689900082 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689900082 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Targarona Eduardo Division of Surgery, Hospital Clinic, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Pons María José Division of Surgery, Hospital Clinic, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Balagué Carmen Division of Surgery, Hospital Clinic, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Espert Juan José Division of Surgery, Hospital Clinic, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Moral Antonio Division of Surgery, Hospital Clinic, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Martínez Joaquín Division of Surgery, Hospital Clinic, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Gaya Juan Laboratory of Hormonal Biochemistry, Hospital Clinic, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Filella Xavier Laboratory of Biochemistry, Hospital Clinic, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Rivera Francisca Laboratory of Biochemistry, Hospital Clinic, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Ballesta Antonio Laboratory of Biochemistry, Hospital Clinic, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 700 1- Trías Manuel Division of Surgery, Hospital Clinic, University of Barcelona, Villarroel 170, 08036, Barcelona, Spain aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 20/5(1996-06-01), 528-534 0364-2313 20:5<528 1996 20 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer