caa a22 4500 477036430 CHVBK 20180405111306.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/s002689900091 doi (NATIONALLICENCE)springer-10.1007/s002689900091 Peritoneal Carcinomatosis from Adenocarcinoma of the Colon [Elektronische Daten] [Paul Sugarbaker, Monique Schellinx, David Chang, Patricia Koslowe, Maarten von Meyerfeldt] Peritoneal carcinomatosis is a major cause of surgical treatment failure in patients with colorectal cancer. In the past patients with this condition have had a lethal outcome. In this study, 64 consecutive patients were treated by the cytoreductive approach, which involved surgery to maximally resect all cancer in the abdomen and pelvis, early postoperative intraperitoneal chemotherapy with 5-fluorouracil (5-FU) and mitomycin C, and three cycles of adjuvant intraperitoneal 5-FU with systemic mitomycin C. The clinical features that may affect prognosis were assessed and critically analyzed statistically. Peritoneal implant size of < 5 cm present in the abdomen and pelvis at the time of exploration correlated with a good prognosis (p < 0.0001), as did complete cytoreduction with tumor removed to nodules < 2.5 mm (p < 0.0001). Involvement of only one or two of the five abdominopelvic regions, compared to three or more regions, was a significant determinant of prognosis (p < 0.0001). Finally, a mucinous histologic type correlated adversely with prognosis when compared to intestinal-type adenocarcinomas (p < 0.001). These data suggest that patients with small-volume peritoneal seeding from colon cancer should be treated with cytoreductive surgery and aggressive regional and systemic chemotherapy in an attempt to achieve long-term disease-free survival. Société Internationale de Chirugie, 1996 Sugarbaker Paul Washington Cancer Institute, Washington Hospital Center, 110 Irving N.W., 20010, Washington, D.C., U.S.A. aut Schellinx Monique University Hospital Maastricht, 6202 AZ, Maastricht, The Netherlands aut Chang David Epistat, 700 Burnt Mills Avenue, 20901, Silver Spring, Maryland, U.S.A. aut Koslowe Patricia Epistat, 700 Burnt Mills Avenue, 20901, Silver Spring, Maryland, U.S.A. aut von Meyerfeldt Maarten University Hospital Maastricht, 6202 AZ, Maastricht, The Netherlands aut World Journal of Surgery Springer-Verlag 20/5(1996-06-01), 585-592 0364-2313 20:5<585 1996 20 268 https://doi.org/10.1007/s002689900091 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689900091 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sugarbaker Paul Washington Cancer Institute, Washington Hospital Center, 110 Irving N.W., 20010, Washington, D.C., U.S.A aut NATIONALLICENCE 700 1- Schellinx Monique University Hospital Maastricht, 6202 AZ, Maastricht, The Netherlands aut NATIONALLICENCE 700 1- Chang David Epistat, 700 Burnt Mills Avenue, 20901, Silver Spring, Maryland, U.S.A aut NATIONALLICENCE 700 1- Koslowe Patricia Epistat, 700 Burnt Mills Avenue, 20901, Silver Spring, Maryland, U.S.A aut NATIONALLICENCE 700 1- von Meyerfeldt Maarten University Hospital Maastricht, 6202 AZ, Maastricht, The Netherlands aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 20/5(1996-06-01), 585-592 0364-2313 20:5<585 1996 20 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer