caa a22 4500 477036473 CHVBK 20180405111306.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/s002689900081 doi (NATIONALLICENCE)springer-10.1007/s002689900081 Low-Molecular-Weight Heparin versus Warfarin for Prevention of Recurrent Venous Thromboembolism: A Randomized Trial [Elektronische Daten] [S. Das, A. Cohen, R. Edmondson, E. Melissari, V. Kakkar] A group of 105 consecutive patients with venographically proved major acute deep vein thrombosis (DVT) were randomized in an open prospective study to evaluate the comparative efficacy and safety of a fixed dose of subcutaneous low-molecular-weight heparin (LMWH) and warfarin for the prevention of recurrent venous thromboembolism. Four patients developed venographically proved recurrent DVT during the 3 months of treatment: three in the LMWH group and one in the warfarin group. Nonfatal pulmonary embolism occurred in two patients in the LMWH group and in one in the warfarin group. Five of the 55 patients (10%) in the warfarin group and none of the 50 patients in the LMWH developed bleeding complications (two-tailed Fisher exact test, p = 0.06). A preliminary assessment of the costs indicated that treatment with LMWH was less expensive by £900 per patient than warfarin. In conclusion, the fixed daily dose of LMWH and the adjusted dose of warfarin therapy were of similar efficacy in preventing recurrence of DVT. However, warfarin therapy, despite strict laboratory control, is associated with more frequent side effects and is expensive. Another study with a higher dose of LMWH is recommended. Société Internationale de Chirugie, 1996 Das S. Thrombosis Research Institute, Emmanuel Kaye Building, Manresa Road, SW3 6LR, Chelsea, London, UK aut Cohen A. Thrombosis Research Institute, Emmanuel Kaye Building, Manresa Road, SW3 6LR, Chelsea, London, UK aut Edmondson R. Thrombosis Research Institute, Emmanuel Kaye Building, Manresa Road, SW3 6LR, Chelsea, London, UK aut Melissari E. Thrombosis Research Institute, Emmanuel Kaye Building, Manresa Road, SW3 6LR, Chelsea, London, UK aut Kakkar V. Thrombosis Research Institute, Emmanuel Kaye Building, Manresa Road, SW3 6LR, Chelsea, London, UK aut World Journal of Surgery Springer-Verlag 20/5(1996-06-01), 521-527 0364-2313 20:5<521 1996 20 268 https://doi.org/10.1007/s002689900081 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689900081 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Das S. Thrombosis Research Institute, Emmanuel Kaye Building, Manresa Road, SW3 6LR, Chelsea, London, UK aut NATIONALLICENCE 700 1- Cohen A. Thrombosis Research Institute, Emmanuel Kaye Building, Manresa Road, SW3 6LR, Chelsea, London, UK aut NATIONALLICENCE 700 1- Edmondson R. Thrombosis Research Institute, Emmanuel Kaye Building, Manresa Road, SW3 6LR, Chelsea, London, UK aut NATIONALLICENCE 700 1- Melissari E. Thrombosis Research Institute, Emmanuel Kaye Building, Manresa Road, SW3 6LR, Chelsea, London, UK aut NATIONALLICENCE 700 1- Kakkar V. Thrombosis Research Institute, Emmanuel Kaye Building, Manresa Road, SW3 6LR, Chelsea, London, UK aut NATIONALLICENCE 773 0- World Journal of Surgery Springer-Verlag 20/5(1996-06-01), 521-527 0364-2313 20:5<521 1996 20 268 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer