caa a22 4500 477036562 CHVBK 20180405111306.0 cr unu---uuuuu 170330e19960201xx s 000 0 eng 10.1007/s002689900026 doi (NATIONALLICENCE)springer-10.1007/s002689900026 Gastric Carcinoids and Neuroendocrine Carcinomas: Pathogenesis, Pathology, and Behavior [Elektronische Daten] [Guido Rindi, Cesare Bordi, Sigrid Rappel, Stefano La Rosa, Manfred Stolte, Enrico Solcia] Abstract. The goal of this study was to provide information of prognostic value for gastric endocrine tumors. A total of 205 gastric endocrine tumors have been studied: 193 well differentiated tumors [2 gastrin cell tumors, 191 enterochromaffin-like (ECL) cell tumors] and 12 poorly differentiated carcinomas. Subtyping of ECL cell tumors (carcinoids) resulted in 152 associated with chronic atrophic gastritis (CAG) (type 1); 12 associated with hypertrophic gastropathy (HG) due to Zollinger-Ellison syndrome with multiple endocrine neoplasia type I (type 2), and 27 with no specific association (type 3, sporadic). Type 1 cases occurred most often in female (108 of 152), elderly (mean 63 years) patients, with no tumor-related death at an overall mean follow-up of 53 months. The 12 type 2 cases were equally distributed between the sexes (six of each), with a mean age of 45 years; there was one tumor-related death (49 months after diagnosis) and an overall mean survival of 84 months. Type 3 cases were mostly in men (20 of 27), with a mean age of 55 years; there were seven tumor-related deaths at a mean follow-up of 28 months. Poorly differentiated neuroendocrine carcinomas were observed in elderly patients (mean 63 years, range 41-76 years) of both sexes, with nine tumor-related deaths and a mean survival of 7 months. It was concluded that correct clinicopathologic subtyping may predict the clinical behavior of gastric endocrine tumors.: 1996 by the Société Internationale de Chir, ugie Rindi Guido Department of Human Pathology and Heredity, University of Pavia, Via Forlanini 16, 27100 Pavia, Italy, IT aut Bordi Cesare Institute of Anatomic Pathology, University of Parma, Via Gramsci 14, 43100 Parma, Italy, IT aut Rappel Sigrid Institute of Pathology Bayreuth, Friedrich-Alexander University of Nuremberg, Preushwitzer Strasse 101, D-95445 Bayreuth, Germany, DE aut La Rosa Stefano Department of Pathology, University of Pavia at Varese, Ospedale di Circolo, Viale Borri 57, 21100 Varese, Italy, IT aut Stolte Manfred Institute of Pathology Bayreuth, Friedrich-Alexander University of Nuremberg, Preushwitzer Strasse 101, D-95445 Bayreuth, Germany, DE aut Solcia Enrico Department of Human Pathology and Heredity, University of Pavia, Via Forlanini 16, 27100 Pavia, Italy, IT aut https://doi.org/10.1007/s002689900026 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689900026 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rindi Guido Department of Human Pathology and Heredity, University of Pavia, Via Forlanini 16, 27100 Pavia, Italy, IT aut NATIONALLICENCE 700 1- Bordi Cesare Institute of Anatomic Pathology, University of Parma, Via Gramsci 14, 43100 Parma, Italy, IT aut NATIONALLICENCE 700 1- Rappel Sigrid Institute of Pathology Bayreuth, Friedrich-Alexander University of Nuremberg, Preushwitzer Strasse 101, D-95445 Bayreuth, Germany, DE aut NATIONALLICENCE 700 1- La Rosa Stefano Department of Pathology, University of Pavia at Varese, Ospedale di Circolo, Viale Borri 57, 21100 Varese, Italy, IT aut NATIONALLICENCE 700 1- Stolte Manfred Institute of Pathology Bayreuth, Friedrich-Alexander University of Nuremberg, Preushwitzer Strasse 101, D-95445 Bayreuth, Germany, DE aut NATIONALLICENCE 700 1- Solcia Enrico Department of Human Pathology and Heredity, University of Pavia, Via Forlanini 16, 27100 Pavia, Italy, IT aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer