caa a22 4500 477036708 CHVBK 20180405111307.0 cr unu---uuuuu 170330e19960201xx s 000 0 eng 10.1007/s002689900035 doi (NATIONALLICENCE)springer-10.1007/s002689900035 Enhanced Expression of Manganese Superoxide Dismutase mRNA and Increased TNFα mRNA Expression by Gastric Mucosa in Gastric Cancer [Elektronische Daten] [Ryo Izutani, Michio Katoh, Satoshi Asano, Harumasa Ohyanagi, Kunitaka Hirose] Abstract. Manganese superoxide dismutase (Mn-SOD), a mitochondrial enzyme, is a cytokine-regulated acute-phase protein that protects cells from free radicals. The current investigations examined the in vivo regulation of the expression of Mn-SOD mRNA and tumor necrosis factor α (TNFα) mRNA in gastric carcinoma tissue. The expression of these transcripts in breast carcinoma tissue also was examined because breast cancer is a much more TNF-sensitive tumor than gastric cancer. TNFα mRNA was markedly increased in gastric carcinoma tissue (: p < 0.005). There were significantly higher levels of Mn-SOD mRNA in gastric carcinoma tissue than in noncancerous tissue ( p < 0.0001). The level of Mn-SOD mRNA in gastric carcinoma tissue was higher than that in breast carcinoma tissue ( p < 0.005). Up-regulation of Mn-SOD mRNA in gastric carcinoma tissue most likely serves as a protective mechanism against superoxide radicals and TNF cytotoxicity. 1996 by the Société Internationale de Chir, ugie Izutani Ryo Second Department of Surgery, Kinki University, School of Medicine, 377-2 Ohno-Higashi, Osaka-Soyama, Osaka 589, Japan, JP aut Katoh Michio Second Department of Surgery, Kinki University, School of Medicine, 377-2 Ohno-Higashi, Osaka-Soyama, Osaka 589, Japan, JP aut Asano Satoshi Second Department of Surgery, Kinki University, School of Medicine, 377-2 Ohno-Higashi, Osaka-Soyama, Osaka 589, Japan, JP aut Ohyanagi Harumasa Second Department of Surgery, Kinki University, School of Medicine, 377-2 Ohno-Higashi, Osaka-Soyama, Osaka 589, Japan, JP aut Hirose Kunitaka Biochemical Research Laboratories, Kureha Chemical Industry Co., 3-26-2, Hyakunin-cho, Shinjuku-ku, Tokyo 160, Japan, JP aut https://doi.org/10.1007/s002689900035 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689900035 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Izutani Ryo Second Department of Surgery, Kinki University, School of Medicine, 377-2 Ohno-Higashi, Osaka-Soyama, Osaka 589, Japan, JP aut NATIONALLICENCE 700 1- Katoh Michio Second Department of Surgery, Kinki University, School of Medicine, 377-2 Ohno-Higashi, Osaka-Soyama, Osaka 589, Japan, JP aut NATIONALLICENCE 700 1- Asano Satoshi Second Department of Surgery, Kinki University, School of Medicine, 377-2 Ohno-Higashi, Osaka-Soyama, Osaka 589, Japan, JP aut NATIONALLICENCE 700 1- Ohyanagi Harumasa Second Department of Surgery, Kinki University, School of Medicine, 377-2 Ohno-Higashi, Osaka-Soyama, Osaka 589, Japan, JP aut NATIONALLICENCE 700 1- Hirose Kunitaka Biochemical Research Laboratories, Kureha Chemical Industry Co., 3-26-2, Hyakunin-cho, Shinjuku-ku, Tokyo 160, Japan, JP aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer