caa a22 4500 477036740 CHVBK 20180405111307.0 cr unu---uuuuu 170330e19960201xx s 000 0 eng 10.1007/s002689900034 doi (NATIONALLICENCE)springer-10.1007/s002689900034 Cholecystokinin Mediation of Colonic Absorption Via Peptide YY: Foregut-Hindgut Axis [Elektronische Daten] [Carson D. Liu, Oscar J. Hines, Todd R. Newton, Thomas E. Adrian, Michael J. Zinner, Stanley W. Ashley, David W. McFadden] Abstract. Peptide YY (PYY), a 36-amino-acid polypeptide, is found in abundance in the colon, a region where its physiologic roles are unknown. Previous studies have revealed a substantial increase in plasma PYY after cholecystokinin (CCK) administration. PYY is released from the hindgut in response to a meal and inhibits CCK release. In this study we evaluated the effects of CCK and PYY on intestinal absorption of water and electrolytes. Colonic, ileal, or jejunal Thiry-Vella fistulas (TVFs) were created in 12 dogs, and intestinal continuity was reestablished. The TVFs were perfused with an isotonic buffer solution containing [14C] PEG as a volume marker. Electrolyte and water transport were measured every 15 minutes, and plasma PYY and CCK levels were measured by radioimmunoassay. Group 1 dogs received an intravenous bolus of MK329, a specific CCK receptor antagonist, at 20 nmol/kg after a standard mixed meal; group 2 colonic TVF dogs received a meal and an intravenous bolus of PYY polyclonal antibody at 1 mg/kg. Postprandially, all three regions of the bowel became significantly proabsorptive for water, sodium, and chloride. In the colon postprandial absorption was abolished by MK329 starting 60 minutes after a meal, whereas specific CCK receptor blockade blunted ileal absorption. CCK receptor blockade did not affect postprandial absorption in the jejunum. Postprandial PYY levels did not rise in MK329-treated animals. PYY antibody reduced colonic absorption during the postprandial phase. Reduction of meal-induced colonic absorption and PYY release by MK329 in awake dogs suggests an important foregut-hindgut hormonal feedback loop. Foregut-derived CCK stimulates hindgut PYY release, which in turn stimulates colonic absorption while inhibiting further CCK release.: 1996 by the Société Internationale de Chir, ugie Liu Carson D. Department of Surgery, UCLA Center for Health Sciences and Sepulveda VA Medical Center, 72-215 CHS, 10833 LeConte Avenue, Los Angeles, California 90024, U.S.A., US aut Hines Oscar J. Department of Surgery, UCLA Center for Health Sciences and Sepulveda VA Medical Center, 72-215 CHS, 10833 LeConte Avenue, Los Angeles, California 90024, U.S.A., US aut Newton Todd R. Department of Surgery, UCLA Center for Health Sciences and Sepulveda VA Medical Center, 72-215 CHS, 10833 LeConte Avenue, Los Angeles, California 90024, U.S.A., US aut Adrian Thomas E. Department of Physiology, Creighton University, 2500 California, Omaha, Nebraska 68131, U.S.A., US aut Zinner Michael J. Department of Surgery, UCLA Center for Health Sciences and Sepulveda VA Medical Center, 72-215 CHS, 10833 LeConte Avenue, Los Angeles, California 90024, U.S.A., US aut Ashley Stanley W. Department of Surgery, UCLA Center for Health Sciences and Sepulveda VA Medical Center, 72-215 CHS, 10833 LeConte Avenue, Los Angeles, California 90024, U.S.A., US aut McFadden David W. Department of Surgery, UCLA Center for Health Sciences and Sepulveda VA Medical Center, 72-215 CHS, 10833 LeConte Avenue, Los Angeles, California 90024, U.S.A., US aut https://doi.org/10.1007/s002689900034 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002689900034 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Liu Carson D. Department of Surgery, UCLA Center for Health Sciences and Sepulveda VA Medical Center, 72-215 CHS, 10833 LeConte Avenue, Los Angeles, California 90024, U.S.A., US aut NATIONALLICENCE 700 1- Hines Oscar J. Department of Surgery, UCLA Center for Health Sciences and Sepulveda VA Medical Center, 72-215 CHS, 10833 LeConte Avenue, Los Angeles, California 90024, U.S.A., US aut NATIONALLICENCE 700 1- Newton Todd R. Department of Surgery, UCLA Center for Health Sciences and Sepulveda VA Medical Center, 72-215 CHS, 10833 LeConte Avenue, Los Angeles, California 90024, U.S.A., US aut NATIONALLICENCE 700 1- Adrian Thomas E. Department of Physiology, Creighton University, 2500 California, Omaha, Nebraska 68131, U.S.A., US aut NATIONALLICENCE 700 1- Zinner Michael J. Department of Surgery, UCLA Center for Health Sciences and Sepulveda VA Medical Center, 72-215 CHS, 10833 LeConte Avenue, Los Angeles, California 90024, U.S.A., US aut NATIONALLICENCE 700 1- Ashley Stanley W. Department of Surgery, UCLA Center for Health Sciences and Sepulveda VA Medical Center, 72-215 CHS, 10833 LeConte Avenue, Los Angeles, California 90024, U.S.A., US aut NATIONALLICENCE 700 1- McFadden David W. Department of Surgery, UCLA Center for Health Sciences and Sepulveda VA Medical Center, 72-215 CHS, 10833 LeConte Avenue, Los Angeles, California 90024, U.S.A., US aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer