caa a22 4500 477037593 CHVBK 20180405111309.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00049484 doi (NATIONALLICENCE)springer-10.1007/BF00049484 Molecular staging of head and neck squamous carcinoma [Elektronische Daten] [Joseph Brennan, David Sidransky] The staging system of head and neck cancer is a Tumor-Node-Metastases system that was developed by the American Joint Committee on Cancer. The stage of the head and neck cancer defines the extent of the lesion and is determined by physical examination, radiologic studies, and pathologic examination. Accurate staging of head and neck cancer is critical since it will determine the treatment modalities used to cure the disease. Recent advances in the field of molecular genetics have allowed clinicians to detect occult cancer cells previously missed by physical examination and standard histopathologic techniques. Molecular assays are 500 times more sensitive in identifying cancer cells than standard techniques and provide more objective analyses with fewer sampling errors. Consequently, these techniques are currently being used to perform molecular staging of head and neck cancer patients. Preliminary results show that molecular staging will accurately identify those patients at significantly increased risk for recurrence of their head and neck cancer. Kluwer Academic Publishers, 1996 molecular nationallicence genetics nationallicence p53 nationallicence staging nationallicence mutations nationallicence prognosis nationallicence Brennan Joseph Otolaryngology/Head and Neck Surgery, David Grant Medical Center, Travis Air Force Base, California, USA aut Sidransky David Division of Head and Neck Cancer Research, The Johns Hopkins Hospital, Baltimore, Maryland, USA aut Cancer and Metastasis Reviews Kluwer Academic Publishers; http://www.wkap.nl 15/1(1996-03-01), 3-10 0167-7659 15:1<3 1996 15 10555 https://doi.org/10.1007/BF00049484 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00049484 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brennan Joseph Otolaryngology/Head and Neck Surgery, David Grant Medical Center, Travis Air Force Base, California, USA aut NATIONALLICENCE 700 1- Sidransky David Division of Head and Neck Cancer Research, The Johns Hopkins Hospital, Baltimore, Maryland, USA aut NATIONALLICENCE 773 0- Cancer and Metastasis Reviews Kluwer Academic Publishers; http://www.wkap.nl 15/1(1996-03-01), 3-10 0167-7659 15:1<3 1996 15 10555 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer