caa a22 4500 477037631 CHVBK 20180405111309.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00049485 doi (NATIONALLICENCE)springer-10.1007/BF00049485 Biological staging of head and neck cancer and its role in developing effective treatment strategies [Elektronische Daten] [William Lydiatt, Stimson Schantz] The purpose of a cancer staging system is to encompass all attributes of a tumor that define its life history. We propose a biological staging system which incorporates all of the phases of the natural history of head and neck cancer beginning with the earliest cellular changes extending through the early phase of invasion to the occurrence of metastasis and, finally, culminating in therapeutically refractory disease. This temporally structured system recognizes the importance of constitutional predisposition, and the impact of environmental factors. The intent is to augment the AJCC/UICC staging system and use this system to provide a framework which will easily incorporate current and future advances in basic science, prevention, therapy and palliation which will improve the quality and quantity of life for patients. Kluwer Academic Publishers, 1996 staging nationallicence biological nationallicence head and neck cancer nationallicence treatment nationallicence Lydiatt William Department of Surgery, Head and Neck Service, 1275 York Avenue, USA aut Schantz Stimson Department of Surgery, Head and Neck Service, 1275 York Avenue, USA aut Cancer and Metastasis Reviews Kluwer Academic Publishers; http://www.wkap.nl 15/1(1996-03-01), 11-25 0167-7659 15:1<11 1996 15 10555 https://doi.org/10.1007/BF00049485 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00049485 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lydiatt William Department of Surgery, Head and Neck Service, 1275 York Avenue, USA aut NATIONALLICENCE 700 1- Schantz Stimson Department of Surgery, Head and Neck Service, 1275 York Avenue, USA aut NATIONALLICENCE 773 0- Cancer and Metastasis Reviews Kluwer Academic Publishers; http://www.wkap.nl 15/1(1996-03-01), 11-25 0167-7659 15:1<11 1996 15 10555 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer