caa a22 4500 477037666 CHVBK 20180405111309.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00049491 doi (NATIONALLICENCE)springer-10.1007/BF00049491 Programmed cell death and radioresistance [Elektronische Daten] [Ravmond Meyn, Clifton Stephens, Luka Milas] Whereas apoptosis is a critical mode of cell deletion in normal organism development, apoptotic cells are also observed in tumors, especially following cytotoxic treatments, leading to questions about their role in tumor response to therapy. We have conducted a series of studies using murine tumor models and found that the ability of the tumor cells to undergo apoptosis correlates with tumor response to radiation. The best correlation was with the pretreatment apoptotic index, suggesting that apoptosis in some tumors may govern radiocurability by regulating the number of tumor clonogens. However, other roles for apoptosis in tumor response to radiation have not been ruled out. One of the important observations that has come from this work has been the heterogeneity in apoptosis propensity both within the cell population of a given tumor and among different types of tumors. Such findings underscore the fact that apoptosis is under complex genetic control and that some of the same oncogenes and tumor suppressor genes that are responsible for tumor initiation and progression to malignancy also dictate the apoptotic response to treatment. Understanding the biochemical and molecular pathways that govern this process may ultimately allow the development of strategies for modulating apoptosis for therapeutic benefit. Kluwer Academic Publishers, 1996 apoptosis nationallicence radiation nationallicence programmed cell death nationallicence tumor nationallicence murine nationallicence Meyn Ravmond Department of Experimental Radiotherapy, The University of Texas M.D. Anderson Cancer Center, 77030, Houston, Texas, USA aut Stephens Clifton Veterinary Medicine and Surgery, The University of Texas M.D. Anderson Cancer Center, 77030, Houston, Texas, USA aut Milas Luka Department of Experimental Radiotherapy, The University of Texas M.D. Anderson Cancer Center, 77030, Houston, Texas, USA aut Cancer and Metastasis Reviews Kluwer Academic Publishers; http://www.wkap.nl 15/1(1996-03-01), 119-131 0167-7659 15:1<119 1996 15 10555 https://doi.org/10.1007/BF00049491 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00049491 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Meyn Ravmond Department of Experimental Radiotherapy, The University of Texas M.D. Anderson Cancer Center, 77030, Houston, Texas, USA aut NATIONALLICENCE 700 1- Stephens Clifton Veterinary Medicine and Surgery, The University of Texas M.D. Anderson Cancer Center, 77030, Houston, Texas, USA aut NATIONALLICENCE 700 1- Milas Luka Department of Experimental Radiotherapy, The University of Texas M.D. Anderson Cancer Center, 77030, Houston, Texas, USA aut NATIONALLICENCE 773 0- Cancer and Metastasis Reviews Kluwer Academic Publishers; http://www.wkap.nl 15/1(1996-03-01), 119-131 0167-7659 15:1<119 1996 15 10555 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer