caa a22 4500 477037690 CHVBK 20180405111309.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00049492 doi (NATIONALLICENCE)springer-10.1007/BF00049492 Ensley John Department of Internal Medicine, Division of Hematology-Oncology, Wayne State University, Detroit, Michigan, USA aut The clinical application of DNA content and kinetic parameters in the treatment of patients with squamous cell carcinomas of the head and neck [Elektronische Daten] [John Ensley] Patients with squamous cell cancers of the head and neck (SCCHN) vary tremendously in their natural history and treatment outcome even amongst subgroups where the clinical and morphological parameters are similar. The ability to pretherapeutically identify individual patients and patient subgroups that differ in these regards would greatly facilitate clinical and basic science cancer research in this tumor. DNA content parameters are simple and accurate intermediate markers of a tumor's biology and reflect the fundamental process associated with the development of malignancy, chromosomal aneuploidy. In patients with SCCHN, DNA content parameters have been shown to be highly predictive of the natural history of the tumor and treatment outcome. They are also useful as intermediate markers for the study of the underlying molecular-genetic properties and processes responsible for the biological differences seen in these cancers. DNA content parameters therefore serve as fundamental ‘translational' bridges in clinical and laboratory research in patients with SCCHN. Kluwer Academic Publishers, 1996 squamous cell carcinomas of the head and neck (SCCHN) nationallicence DNA content parameters nationallicence flow cytometry nationallicence DNA ploidy nationallicence percent S phase fraction nationallicence tumor response nationallicence treatment outcome nationallicence Cancer and Metastasis Reviews Kluwer Academic Publishers; http://www.wkap.nl 15/1(1996-03-01), 133-141 0167-7659 15:1<133 1996 15 10555 https://doi.org/10.1007/BF00049492 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00049492 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Ensley John Department of Internal Medicine, Division of Hematology-Oncology, Wayne State University, Detroit, Michigan, USA aut NATIONALLICENCE 773 0- Cancer and Metastasis Reviews Kluwer Academic Publishers; http://www.wkap.nl 15/1(1996-03-01), 133-141 0167-7659 15:1<133 1996 15 10555 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer