caa a22 4500 477037712 CHVBK 20180405111309.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF00049490 doi (NATIONALLICENCE)springer-10.1007/BF00049490 Clinical studies in head and neck cancer chemoprevention [Elektronische Daten] [Pablo Gonzalez, Steven Benner] Secondary neoplasms represent a major threat for patients with head and neck cancer. The prevention of secondary neoplasms has been a major goal of head and neck cancer chemoprevention efforts. In order to help develop effective strategies, reversal of oral premalignancy has been used as a model for chemoprevention. There is now sufficient data to show the chemopreventive effect in premalignant lesions of some natural compounds and their derivatives. Retinoids are the most studied chemopreventive agents for the treatment of oral leukoplakia. Other compounds with chemopreventive activity are carotenoids, Vitamin E derivatives and Selenium. There are two large prospective, randomized, chemoprevention clinical trials, one in Europe and the other in North America, using prevention of secondary malignancy as the primary study end-point. Until these trials are completed, the use of chemoprevention in head and neck cancer should be limited to clinical trials. Kluwer Academic Publishers, 1996 chemoprevention nationallicence head and neck nationallicence cancer nationallicence retinoids nationallicence secondary neoplasms nationallicence Gonzalez Pablo Division of Hematology/Oncology, University of North Carolina at Chapel Hill, USA aut Benner Steven Division of Hematology/Oncology, University of North Carolina at Chapel Hill, USA aut Cancer and Metastasis Reviews Kluwer Academic Publishers; http://www.wkap.nl 15/1(1996-03-01), 113-118 0167-7659 15:1<113 1996 15 10555 https://doi.org/10.1007/BF00049490 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00049490 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gonzalez Pablo Division of Hematology/Oncology, University of North Carolina at Chapel Hill, USA aut NATIONALLICENCE 700 1- Benner Steven Division of Hematology/Oncology, University of North Carolina at Chapel Hill, USA aut NATIONALLICENCE 773 0- Cancer and Metastasis Reviews Kluwer Academic Publishers; http://www.wkap.nl 15/1(1996-03-01), 113-118 0167-7659 15:1<113 1996 15 10555 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer