caa a22 4500 477037755 CHVBK 20180405111309.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF00046344 doi (NATIONALLICENCE)springer-10.1007/BF00046344 Direct cell killing by suicide genes [Elektronische Daten] [L.-A. Martin, N. Lemoine] Cell death can be induced by genetic intervention in a variety of ways. We review genetic prodrug activation therapies using both mammalian and non-mammalian enzyme systems as well as the expression of toxin genes and apoptotic triggers. Targeting of the genetic intervention using both transductional restriction and transcriptional control elements is examined in both in vitro and in vivo systems, and the present state of clinical trials is reviewed. Kluwer Academic Publishers, 1996 suicide genes nationallicence gene therapy nationallicence transcriptional control nationallicence Martin L.-A ICRF Oncology Unit, Royal Postgraduate Medical School, Hammersmith Hospital, W12 0NN, London, UK aut Lemoine N. ICRF Oncology Unit, Royal Postgraduate Medical School, Hammersmith Hospital, W12 0NN, London, UK aut Cancer and Metastasis Reviews Kluwer Academic Publishers 15/3(1996-09-01), 301-316 0167-7659 15:3<301 1996 15 10555 https://doi.org/10.1007/BF00046344 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00046344 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Martin L.-A ICRF Oncology Unit, Royal Postgraduate Medical School, Hammersmith Hospital, W12 0NN, London, UK aut NATIONALLICENCE 700 1- Lemoine N. ICRF Oncology Unit, Royal Postgraduate Medical School, Hammersmith Hospital, W12 0NN, London, UK aut NATIONALLICENCE 773 0- Cancer and Metastasis Reviews Kluwer Academic Publishers 15/3(1996-09-01), 301-316 0167-7659 15:3<301 1996 15 10555 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer