caa a22 4500 477037771 CHVBK 20180405111309.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF00046345 doi (NATIONALLICENCE)springer-10.1007/BF00046345 Immunotherapy I: Cyclosine gene transfer strategies [Elektronische Daten] [Mario Colombo, Guido Forni] The cytokine approach to gene therapy of cancer stems from early studies of direct, repeated injection of recombinant cytokines at the tumor site, and extension of the bystander effect that enables a few cytokine gene transduced cells in a tumor to bring about its total destruction. This effect can be extended through the immune system, since cytokine-activated regression of a small mass of tumor cells can afford systemic protection. Transduced cells used as a vaccine provide a local concentration of both cytokine and tumor antigens. Cytokines sustain antigen uptake and presentation by increasing the immunogenic potential of the environment through the recruitment of antigen presenting cells and leukocytes, and activation of a cascade of events which amplify and tone up the efficacy of a vaccine. The promises and difficulties of this approach are discussed by considering what is still missing from experimental studies and what can best be done as soon as possible in animals and humans to reach compelling conclusions. Kluwer Academic Publishers, 1996 cytokine nationallicence tumor nationallicence gene transfer nationallicence immunotherapy nationallicence Colombo Mario Gene Therapy Program and Experimental Oncology D, Istituto Nazionale Tumori, 20133, Milan aut Forni Guido Gene Therapy Program and Experimental Oncology D, Istituto Nazionale Tumori, 20133, Milan aut Cancer and Metastasis Reviews Kluwer Academic Publishers 15/3(1996-09-01), 317-328 0167-7659 15:3<317 1996 15 10555 https://doi.org/10.1007/BF00046345 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00046345 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Colombo Mario Gene Therapy Program and Experimental Oncology D, Istituto Nazionale Tumori, 20133, Milan aut NATIONALLICENCE 700 1- Forni Guido Gene Therapy Program and Experimental Oncology D, Istituto Nazionale Tumori, 20133, Milan aut NATIONALLICENCE 773 0- Cancer and Metastasis Reviews Kluwer Academic Publishers 15/3(1996-09-01), 317-328 0167-7659 15:3<317 1996 15 10555 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 477037771 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer