caa a22 4500 477037801 CHVBK 20180405111309.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF00046347 doi (NATIONALLICENCE)springer-10.1007/BF00046347 Immunotherapy III: Combinatorial molecular immunotherapy-a synthesis and suggestions [Elektronische Daten] [Richard Vile, Heung Chong] Animal models have clearly shown that tumor cells may be amenable to molecular manipulation which can result in immune activation and rejection of unmodified cells (Chapters 4 and 5). The challenge now is to design clinical trials which have a realistic chance of success, although the definition of ‘success' is itself an important issue [see Chapter 9]. How should such a strategy be formulated? A review of the previous fifteen years since the first (immune) gene transfer studies were reported, encompasses a great wealth of data. Unfortunately, far from crystallising a set of unifying principles, these diverse reports shroud us in a fog of uncertainty as to how best to proceed. However, if this technology is to have practical, widespread application in the treatment of cancer patients, it is necessary to identify certain critical immunological goals which any protocols should achieve. Clear elucidation of these goals, by unifying the huge amount of disparate experimental data, must eventually be accomplished. In this chapter, we have reviewed the literature covering the era of molecular immunotherapy. We propose four general goals around which widely applicable clinical protocols, not necessarily dependent upon tumour type or experimental bias, might be based and suggest how they may be achieved in the context of gene transfer. Kluwer Academic Publishers, 1996 immunotherapy nationallicence gene therapy nationallicence cytokines nationallicence antigen presentation nationallicence Vile Richard Imperial Cancer Research Fund Laboratory of Cancer Gene Therapy, St. Thomas' Hospital, London, UK aut Chong Heung Imperial Cancer Research Fund Laboratory of Cancer Gene Therapy, St. Thomas' Hospital, London, UK aut Cancer and Metastasis Reviews Kluwer Academic Publishers 15/3(1996-09-01), 351-364 0167-7659 15:3<351 1996 15 10555 https://doi.org/10.1007/BF00046347 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00046347 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vile Richard Imperial Cancer Research Fund Laboratory of Cancer Gene Therapy, St. Thomas' Hospital, London, UK aut NATIONALLICENCE 700 1- Chong Heung Imperial Cancer Research Fund Laboratory of Cancer Gene Therapy, St. Thomas' Hospital, London, UK aut NATIONALLICENCE 773 0- Cancer and Metastasis Reviews Kluwer Academic Publishers 15/3(1996-09-01), 351-364 0167-7659 15:3<351 1996 15 10555 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer