caa a22 4500 477037828 CHVBK 20180405111309.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF00046349 doi (NATIONALLICENCE)springer-10.1007/BF00046349 Vectors for cancer gene therapy [Elektronische Daten] [J. Zhang, S. Russell] Many viral and non-viral vector systems have now been developed for gene therapy applications. In this article, the pros and cons of these vector systems are discussed in relation to the different cancer gene therapy strategies. The protocols used in cancer gene therapy can be broadly divided into six categories including gene transfer to explanted cells for use as cell-based cancer vaccines; gene transfer to a small number of tumour cells in situ to achieve a vaccine effect; gene transfer to vascular endothelial cells (VECs) lining the blood vessels of the tumour to interfere with tumour angiogenesis; gene transfer to T lymphocytes to enhance their antitumour effector capability; gene transfer to haemopoietic stem cells (HSCs) to enhance their resistance to cytotoxic drugs and gene transfer to a large number of tumour cells in situ to achieve nonimmune tumour reduction with or without bystander effect. Each of the six strategies makes unique demands on the vector system and these are discussed with reference to currently available vectors. Aspects of vector biology that are in need of further development are discussed in some detail. The final section points to the potential use of replicating viruses as delivery vehicles for efficient in vivo gene transfer to disseminated cancers. Kluwer Academic Publishers, 1996 gene therapy nationallicence cancer nationallicence viral vectors nationallicence non-viral vectors nationallicence replicating vectors nationallicence Zhang J. Division of Transfusion Medicine, Department of Haematology, University of Cambridge, CB2 2PT, Cambridge, UK aut Russell S. Cambridge Centre for Protein Engineering, MRC Centre, Hills Road, CB2 2QH, Cambridge, UK aut Cancer and Metastasis Reviews Kluwer Academic Publishers 15/3(1996-09-01), 385-401 0167-7659 15:3<385 1996 15 10555 https://doi.org/10.1007/BF00046349 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00046349 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhang J. Division of Transfusion Medicine, Department of Haematology, University of Cambridge, CB2 2PT, Cambridge, UK aut NATIONALLICENCE 700 1- Russell S. Cambridge Centre for Protein Engineering, MRC Centre, Hills Road, CB2 2QH, Cambridge, UK aut NATIONALLICENCE 773 0- Cancer and Metastasis Reviews Kluwer Academic Publishers 15/3(1996-09-01), 385-401 0167-7659 15:3<385 1996 15 10555 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer