caa a22 4500 477037844 CHVBK 20180405111309.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/BF00054012 doi (NATIONALLICENCE)springer-10.1007/BF00054012 Oncogenic regulation and function of keratins 8 and 18 [Elektronische Daten] [Robert Oshima, Hélène Baribault, Carlos Caulín] Summary: Keratin 8 (K8) and keratin 18 (K18) are the most common and characteristic members of the large intermediate filament gene family expressed in ‘simple' or single layer epithelial tissues of the body. Their persistent expression in tumor cells derived from these epithelia has led to the wide spread use of keratin monoclonal antibodies as aids in the detection and identification of carcinomas. Oncogenes which activateras signal transduction pathways stimulate expression of the K18 gene through transcription factors including members of the AP-1 (jun and fos) and ETS families. The persistent expression of K8 and K18 may reflect the integrated transcriptional activation of such transcription factors and, in the cases of ectopic expression, an escape from the suppressive epigenetic mechanisms of DNA methylation and chromatin condensation. Comparison of the mechanisms of transcriptional control of K18 expression with expression patterns documented in both normal and pathological conditions leads to the proposal that persistent K8 and K18 expression is a reflection of the action of multiple different oncogenes converging on the nucleus through a limited number of transcription factors to then influence the expression of a large number of genes including these keratins. Furthermore, correlation of various tumor cell characteristics including invasive behavior and drug sensitivity with K8 and K18 expression has stimulated consideration of the possible functions of these proteins in both normal development and in tumorigenesis. Recent developments in the analysis of the functions of these intermediate filament proteins provide new insights into diverse functions influenced by K8 and K18. Kluwer Academic Publishers, 1996 intermediate filament nationallicence keratin nationallicence transcription nationallicence AP-1 nationallicence ETS nationallicence DNA methylation nationallicence carcinoma nationallicence Oshima Robert The Burnham Institute (formerly the La Jolla Cancer Research Foundation), 10901 North Torrey Pines Road, 92037, La Jolla, CA, USA aut Baribault Hélène The Burnham Institute (formerly the La Jolla Cancer Research Foundation), 10901 North Torrey Pines Road, 92037, La Jolla, CA, USA aut Caulín Carlos The Burnham Institute (formerly the La Jolla Cancer Research Foundation), 10901 North Torrey Pines Road, 92037, La Jolla, CA, USA aut Cancer and Metastasis Reviews Kluwer Academic Publishers; http://www.wkap.nl 15/4(1996-12-01), 445-471 0167-7659 15:4<445 1996 15 10555 https://doi.org/10.1007/BF00054012 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00054012 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Oshima Robert The Burnham Institute (formerly the La Jolla Cancer Research Foundation), 10901 North Torrey Pines Road, 92037, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Baribault Hélène The Burnham Institute (formerly the La Jolla Cancer Research Foundation), 10901 North Torrey Pines Road, 92037, La Jolla, CA, USA aut NATIONALLICENCE 700 1- Caulín Carlos The Burnham Institute (formerly the La Jolla Cancer Research Foundation), 10901 North Torrey Pines Road, 92037, La Jolla, CA, USA aut NATIONALLICENCE 773 0- Cancer and Metastasis Reviews Kluwer Academic Publishers; http://www.wkap.nl 15/4(1996-12-01), 445-471 0167-7659 15:4<445 1996 15 10555 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer