caa a22 4500 477037852 CHVBK 20180405111309.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/BF00054011 doi (NATIONALLICENCE)springer-10.1007/BF00054011 Implications of intermediate filament protein phosphorylation [Elektronische Daten] [Nam-On Ku, Jian Liao, Chih-Fong Chou, M. Omary] Summary: Intermediate filament (IF) proteins, a large family of tissue specific proteins, undergo several posttranslational modifications, with phosphorylation being the most studied modification. IF protein phosphorylation is highly dynamic and involves the head and/or tail domains of these proteins, which are the domains that impart most of the structural heterogeneity and hence presumed tissue specific functions. Although the function of IF proteins remains poorly understood, several regulatory roles for IF protein phosphorylation have been identified or are emerging. Those roles include filament disassembly and reorganization, solubility, localization within specific cellular domains, association with other cytoplasmic or membrane associated proteins, protection against physiologic stress and mediation of tissue-specific functions. Understanding the mechanistic and functional aspects of IF protein phosphorylation is providing insights not only regarding the function of this modification, but also regarding the function of IF proteins. Kluwer Academic Publishers, 1996 intermediate filaments nationallicence keratins nationallicence phosphorylation nationallicence Ku Nam-On VA Palo Alto Health Care System, 3801 Miranda Avenue, 111-G.I., 94304, Palo Alto, CA aut Liao Jian VA Palo Alto Health Care System, 3801 Miranda Avenue, 111-G.I., 94304, Palo Alto, CA aut Chou Chih-Fong VA Palo Alto Health Care System, 3801 Miranda Avenue, 111-G.I., 94304, Palo Alto, CA aut Omary M. VA Palo Alto Health Care System, 3801 Miranda Avenue, 111-G.I., 94304, Palo Alto, CA aut Cancer and Metastasis Reviews Kluwer Academic Publishers; http://www.wkap.nl 15/4(1996-12-01), 429-444 0167-7659 15:4<429 1996 15 10555 https://doi.org/10.1007/BF00054011 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00054011 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ku Nam-On VA Palo Alto Health Care System, 3801 Miranda Avenue, 111-G.I., 94304, Palo Alto, CA aut NATIONALLICENCE 700 1- Liao Jian VA Palo Alto Health Care System, 3801 Miranda Avenue, 111-G.I., 94304, Palo Alto, CA aut NATIONALLICENCE 700 1- Chou Chih-Fong VA Palo Alto Health Care System, 3801 Miranda Avenue, 111-G.I., 94304, Palo Alto, CA aut NATIONALLICENCE 700 1- Omary M. VA Palo Alto Health Care System, 3801 Miranda Avenue, 111-G.I., 94304, Palo Alto, CA aut NATIONALLICENCE 773 0- Cancer and Metastasis Reviews Kluwer Academic Publishers; http://www.wkap.nl 15/4(1996-12-01), 429-444 0167-7659 15:4<429 1996 15 10555 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer