caa a22 4500 47703795X CHVBK 20180405111309.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/BF00437469 doi (NATIONALLICENCE)springer-10.1007/BF00437469 Regulation of VEGF/VPF expression in tumor cells: Consequences for tumor growth and metastasis [Elektronische Daten] [Kevin Claffey, Gregory Robinson] Vascular endothelial growth factor (VEGF), also known as vascular permeability factor (VPF) is a multifunctional cytokine which potently stimulates angiogenesis in vivo. VEGF/VPF expression is elevated in pathological conditions including cancer, proliferative retinopathy, psoriasis and rheumatoid arthritis. The angiogenesis associated with human tumors is likely a central component in promoting tumor growth and metastatic potential. The regulation of VEGF/VPF expression during tumor progression may involve diverse mechanisms including activated oncogenes, mutant or deleted tumor suppressor genes, cytokine activation, hormonal modulators, and a particularly effective activator, hypoxia. Understanding the diverse mechanisms by which tumor cells overexpress VEGF/VPF, and which mechanisms are operating in specific tumor types is important for the design of effective anti-cancer therapies. Kluwer Academic Publishers, 1996 angiogenesis nationallicence cancer nationallicence hypoxia nationallicence melanoma nationallicence metastasis nationallicence VEGF nationallicence VPF nationallicence bFGF : basic fibroblast growth factor nationallicence EC : endothelial cell nationallicence EGF : epidermal growth factor nationallicence flk-1 : fetal liver kinase-1 nationallicence flt-1 : fms-like tyrosine kinase-1 nationallicence HIF : hypoxia inducible factor nationallicence KDR : kinase domain receptor nationallicence PDGF : platelet-derived growth factor nationallicence PMA : phorbol 12-myristate 13-acetate nationallicence TGF-β : transforming growth factor-beta nationallicence VEGF : vascular endothelial growth factor nationallicence VPF : vascular permeability factor nationallicence Claffey Kevin Department of Pathology, Beth Israel Hospital, 02215, Boston, MA, USA aut Robinson Gregory Hybridon, Inc., 01605, MA, USA aut Cancer and Metastasis Reviews Kluwer Academic Publishers; http://www.wkap.nl 15/2(1996-06-01), 165-176 0167-7659 15:2<165 1996 15 10555 https://doi.org/10.1007/BF00437469 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00437469 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Claffey Kevin Department of Pathology, Beth Israel Hospital, 02215, Boston, MA, USA aut NATIONALLICENCE 700 1- Robinson Gregory Hybridon, Inc., 01605, MA, USA aut NATIONALLICENCE 773 0- Cancer and Metastasis Reviews Kluwer Academic Publishers; http://www.wkap.nl 15/2(1996-06-01), 165-176 0167-7659 15:2<165 1996 15 10555 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer