caa a22 4500 477038123 CHVBK 20180405111310.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/BF00437476 doi (NATIONALLICENCE)springer-10.1007/BF00437476 Treating cancer by inhibiting angiogenesis: new hopes and potential pitfall [Elektronische Daten] [J. Rak, R. Kerbel] Summary: Angiogenesis is essential for progressive solid tumor growth and thus constitutes a very promising therapeutic target. Recent developments in understanding of the molecular mechanisms involved in tumor blood vessel formation provides a rational basis for anti-angiogenic drug development, especially of more selective and effective agents. However, for the very same reason, it is time to think more critically about some of the potential pitfalls and difficulties associated with this treatment strategy and of research needed to define realistic expectations in this area. Kluwer Academic Publishers, 1996 angiogenesis dependence nationallicence oncogenes nationallicence VEGF nationallicence Rak J. Reichmann Research Building, Division of Cancer Biology Research, Sunnybrook Health Science Centre, 2075 Bayview Avenue, S-218, M4N 3M5, Toronto, Ontario, Canada aut Kerbel R. Reichmann Research Building, Division of Cancer Biology Research, Sunnybrook Health Science Centre, 2075 Bayview Avenue, S-218, M4N 3M5, Toronto, Ontario, Canada aut Cancer and Metastasis Reviews Kluwer Academic Publishers; http://www.wkap.nl 15/2(1996-06-01), 231-236 0167-7659 15:2<231 1996 15 10555 https://doi.org/10.1007/BF00437476 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00437476 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rak J. Reichmann Research Building, Division of Cancer Biology Research, Sunnybrook Health Science Centre, 2075 Bayview Avenue, S-218, M4N 3M5, Toronto, Ontario, Canada aut NATIONALLICENCE 700 1- Kerbel R. Reichmann Research Building, Division of Cancer Biology Research, Sunnybrook Health Science Centre, 2075 Bayview Avenue, S-218, M4N 3M5, Toronto, Ontario, Canada aut NATIONALLICENCE 773 0- Cancer and Metastasis Reviews Kluwer Academic Publishers; http://www.wkap.nl 15/2(1996-06-01), 231-236 0167-7659 15:2<231 1996 15 10555 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer