caa a22 4500 477038131 CHVBK 20180405111310.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/BF00437480 doi (NATIONALLICENCE)springer-10.1007/BF00437480 Liver endothelial cells: participation in host response to lymphoma metastasis [Elektronische Daten] [Victor Umansky, Marian Rocha, Volker Schirrmacher] Interactions between metastasizing tumor cells and host cells in target organs determine the outcome of metastasis. This review discusses the dual role of activated host endothelial cells in the metastatic process. On one hand, the upregulation of the expression of particular adhesion molecules leads to increased tumor cell binding, and the stimulation of angiogenesis provides the vascular support for the growth of already established metastases. On the other hand, endothelial cells can contribute to host anti-metastatic responses, e.g. by production of the cytotoxic molecule nitric oxide (NO) from arginine with the help of the inducible nitric oxide synthase (iNOS). Using a well-characterized ESbL-lacZ mouse T lymphoma model with a typical three phasic growth profile, we showed during the period of growth retardation a stimulation of NO production by ex vivo isolated liver sinusoidal endothelial cells. The induction of NO synthesis in liver endothelial cells did not require the presence of Kupffer cells and appeared to be stimulated by and dependent on mature T lymphocytes. A breakdown of this NO synthesis coincided with the second tumor expansion phase. Kluwer Academic Publishers, 1996 endothelial NO production nationallicence inducible nitric oxide synthase (INOS) nationallicence liver sinusoidal endothelial cells nationallicence IL : interleukin nationallicence TGF : transforming growth factor nationallicence VEGF : vascular endothelial growth factor nationallicence PG : prostaglandin nationallicence bFGF : basic fibroblast growth factor nationallicence TNF : tumor necrosis factor nationallicence ICAM-1 : intercellular adhesion molecule-1 nationallicence VCAM-1 : vascular cell adhesion molecule nationallicence VLA-4 : very late activated antigen nationallicence LFA-1 : leucocyte function-associated antigen nationallicence NO : nitric oxide nationallicence iNOS : inducible NO synthase nationallicence NK-κB : nuclear factor kappa B nationallicence IFN-γ : interferon γ nationallicence CL2MBP : dichloromethylenebisphosphonate nationallicence Umansky Victor The Tumor Immunology Program, Division of Cellular Immunology, German Cancer Research Center, Heidelberg, Germany aut Rocha Marian The Tumor Immunology Program, Division of Cellular Immunology, German Cancer Research Center, Heidelberg, Germany aut Schirrmacher Volker The Tumor Immunology Program, Division of Cellular Immunology, German Cancer Research Center, Heidelberg, Germany aut Cancer and Metastasis Reviews Kluwer Academic Publishers; http://www.wkap.nl 15/2(1996-06-01), 273-279 0167-7659 15:2<273 1996 15 10555 https://doi.org/10.1007/BF00437480 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00437480 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Umansky Victor The Tumor Immunology Program, Division of Cellular Immunology, German Cancer Research Center, Heidelberg, Germany aut NATIONALLICENCE 700 1- Rocha Marian The Tumor Immunology Program, Division of Cellular Immunology, German Cancer Research Center, Heidelberg, Germany aut NATIONALLICENCE 700 1- Schirrmacher Volker The Tumor Immunology Program, Division of Cellular Immunology, German Cancer Research Center, Heidelberg, Germany aut NATIONALLICENCE 773 0- Cancer and Metastasis Reviews Kluwer Academic Publishers; http://www.wkap.nl 15/2(1996-06-01), 273-279 0167-7659 15:2<273 1996 15 10555 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer