caa a22 4500 477038190 CHVBK 20180405111310.0 cr unu---uuuuu 170330e19960201xx s 000 0 eng 10.1007/BF02740745 doi (NATIONALLICENCE)springer-10.1007/BF02740745 Physiological relevance and functional potential of central nervous system-derived cell lines [Elektronische Daten] [Scott Whittemore, Evan Snyder] Central nervous system (CNS)-derived neural cell lines have proven to be extremely useful for delineating mechanisms controlling such diverse phenomena as cell lineage choice and differentiation, synaptic maturation, neurotransmitter synthesis and release, and growth factor signalling. In addition, there has been hope that such lines might play pivotal roles in CNS gene therapy and repair. The ability of some neural cell lines to integrate normally into the CNS following transplantation and to express foreign, often corrective gene productsin situ might offer potential therapeutic approaches to certain neurodegenerative diseases. Five general strategies have evolved to develop neural cell lines: isolation and cloning of spontaneous or mutagenically induced malignancies, targeted oncogenesis in transgenic mice, somatic cell fusion, growth factor mediated expansion of CNS progenitor or stem cells, and retroviral transduction of neuroepithelial precursors. In this article, we detail recent progress in these areas, focusing on those cell lines that have enabled novel insight into the mechanisms controlling neuronal cell lineage choice and differentiation, both in vitro and in vivo. Humana Press Inc, 1996 Cell lines nationallicence retroviral transduction nationallicence somatic cell fusion nationallicence stem cells nationallicence progenitor/precursor cells nationallicence transgenic mice nationallicence targeted oncogenesis nationallicence differentiation nationallicence cell lineage nationallicence transplantation nationallicence gene therapy nationallicence neurodegeneration nationallicence Whittemore Scott The Miami Project and Departments of Neurological Surgery, and Physiology and Biophysics, University of Miami School of Medicine, Miami, FL aut Snyder Evan Department of Neurology and Pediatrics, Harvard Medical School, Children's Hospital, Boston, MA aut Molecular Neurobiology Humana Press 12/1(1996-02-01), 13-38 0893-7648 12:1<13 1996 12 12035 https://doi.org/10.1007/BF02740745 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02740745 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Whittemore Scott The Miami Project and Departments of Neurological Surgery, and Physiology and Biophysics, University of Miami School of Medicine, Miami, FL aut NATIONALLICENCE 700 1- Snyder Evan Department of Neurology and Pediatrics, Harvard Medical School, Children's Hospital, Boston, MA aut NATIONALLICENCE 773 0- Molecular Neurobiology Humana Press 12/1(1996-02-01), 13-38 0893-7648 12:1<13 1996 12 12035 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer