caa a22 4500 477038204 CHVBK 20180405111310.0 cr unu---uuuuu 170330e19960201xx s 000 0 eng 10.1007/BF02740746 doi (NATIONALLICENCE)springer-10.1007/BF02740746 Chalazonitis Alcmène Department of Anatomy and Cell Biology, Columbia University, College of Physicians and Surgeons, 630 W. 168th Street, 10032, New York, NY aut Neurotrophin-3 as an essential signal for the developing nervous system [Elektronische Daten] [Alcmène Chalazonitis] Rapid advances in characterization of the biological actions mediated by the third member of the neurotrophin family, neurotrophin-3 (NT-3), have been made recently in vitro as well asin situ. These have been made possible by the cloning of the genes for NT-3 and for its transducing receptor tyrosine kinase TrkC. This article will focus on the roles of NT-3 in the nervous system.In situ localization of NT-3 consistent with that of its receptor is manifested at all developmental stages studied and into adulthood. Through TrkC, NT-3 signals a number of trophic effects, ranging from mitogenesis, promotion of survival, or differentiation, depending on the developmental stage of the target cells. The sites of action of NT-3 reside primarily in the peripheral nervous system (PNS), various areas of the central nervous system (CNS), and in the enteric nervous system (ENS). Analyses of the phenotypes of transgenic mice lacking NT-3 or injection of embryos with a blocking antibody have so far revealed the essential role of NT-3 in development of specific populations of the PNS, and in particular of proprioceptive, nodose, and auditory sensory neurons and of sympathetic neurons. The actions of NT-3 also extend to modulation of transmitter release at several types of synapses in the periphery as well as in the adult CNS. In addition, NT-3 may play a role in the development of tissues other than the nervous system, such as the cardiovascular system. Future investigations will widen the understanding of the many roles of NT-3 on both neuronal and nonneuronal cells. Humana Press Inc, 1996 Neurotrophic factors nationallicence NT-3 nationallicence differentiation nationallicence neurons nationallicence glia nationallicence peripheral nationallicence enteric nationallicence central nervous systems nationallicence TrkC nationallicence receptor isoforms nationallicence NT-3 antibody nationallicence transgenic mice nationallicence Molecular Neurobiology Humana Press 12/1(1996-02-01), 39-53 0893-7648 12:1<39 1996 12 12035 https://doi.org/10.1007/BF02740746 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02740746 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Chalazonitis Alcmène Department of Anatomy and Cell Biology, Columbia University, College of Physicians and Surgeons, 630 W. 168th Street, 10032, New York, NY aut NATIONALLICENCE 773 0- Molecular Neurobiology Humana Press 12/1(1996-02-01), 39-53 0893-7648 12:1<39 1996 12 12035 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer