caa a22 4500 477038239 CHVBK 20180405111310.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/BF02755590 doi (NATIONALLICENCE)springer-10.1007/BF02755590 Regulation of gap junction coupling in the developing neocortex [Elektronische Daten] [Birgit Rörig, Bernd Sutor] In the developing mammalian, neocortex gap junctions represent a transient, metabolic, and electrical communication system. These gap junctions may play a crucial role during the formation and refinement of neocortical synaptic circuitries. This article focuses on two major points. First, the influence of gap junctions on electrotonic cell properties will be considered. Both the time-course and the amplitude of synaptic potentials depend,inter alia, on the integration capabilities of the postsynaptic neurons. These capabilities are, to a considerable extent, determined by the electrotonic characteristics of the postsynaptic cell. As a consequence, the efficacy of chemical synaptic inputs may be crucially affected by the presence of gap junctions. The second major topic is the regulation of gap junctional communication by neurotransmitters via second messenger pathways. The monoaminergic neuromodulators dopamine, nordrenaline, and serotonin reduce gap junction coupling via activation of two different intracellular signaling cascades—the cAMP/protein kinase A pathway and the IP3/Ca2+/protein kinase C pathway, 013 respectively. In addition, gap junctional communication seems to be modulated by the nitric oxide (NO)/cGMP system. Since NO production can be stimulated by glutamate-induced calcium influx, the NO/cGMP-dependent modulation of gap junctions might represent a functional link between developing glutamatergic synaptic transmission and the gap junctional network. Thus, it might be of particular importance in view of a role of gap junctions during the process of circuit formation. Humana Press Inc, 1996 Somatosensory cortex nationallicence prefrontal cortex nationallicence gap junction nationallicence development nationallicence pyramidal cell nationallicence electrotonic cell properties nationallicence serotonin nationallicence dopamine nationallicence noradrenaline nationallicence protein kinase A nationallicence cAMP nationallicence nitric oxide nationallicence cGMP nationallicence IP3 nationallicence protein kinase C nationallicence Rörig Birgit Institute of Physiology, University of Munich, Pettenkoferstrasse 12, D-80336, Munich, Germany aut Sutor Bernd Institute of Physiology, University of Munich, Pettenkoferstrasse 12, D-80336, Munich, Germany aut Molecular Neurobiology Humana Press 12/3(1996-06-01), 225-249 0893-7648 12:3<225 1996 12 12035 https://doi.org/10.1007/BF02755590 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02755590 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rörig Birgit Institute of Physiology, University of Munich, Pettenkoferstrasse 12, D-80336, Munich, Germany aut NATIONALLICENCE 700 1- Sutor Bernd Institute of Physiology, University of Munich, Pettenkoferstrasse 12, D-80336, Munich, Germany aut NATIONALLICENCE 773 0- Molecular Neurobiology Humana Press 12/3(1996-06-01), 225-249 0893-7648 12:3<225 1996 12 12035 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer