caa a22 4500 477038247 CHVBK 20180405111310.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/BF02755588 doi (NATIONALLICENCE)springer-10.1007/BF02755588 Activating mechanism of CNTF and related cytokines [Elektronische Daten] [Makoto Inoue, Chikao Nakayama, Hiroshi Noguchi] Ciliary neurotrophic factor (CNTF) shares structural and functional properties with members of the hematopoietic cytokine family. It is composed of a four-helix bundle structure and shares the transmembrane signal transducing proteins, glycoprotein-130 (gp130) and leukemia inhibitory factor receptor (LIF-R). Structure-function analysis showed that the gp130-interactive proteins bind in a similar manner to that of growth hormone (sites I and II). In addition, gp130-interactive proteins and granulocyte colony-stimulating factor (G-CSF) utilize another binding site (site III) at the boundary between CD loop and helix D. CNTF triggers the association of receptor components, resulting in activation of a signal transduction cascade mediated by specific intracellular protein tyrosine kinases. The Janus kinase (JAK)/signal transducer and activator of transcription (STAT) and Ras/mitogen-activated protein kinase (MAPK) signaling pathways have been characterized in terms of gp130-interactive protein, and there should be other pathways and some crosstalk between them to enhance, prolong, or specify the signals. Humana Press Inc, 1996 Cytokine nationallicence CNTF nationallicence IL-6 nationallicence LIF nationallicence gp130 nationallicence four-helix bundle nationallicence structure-function nationallicence JAK kinase nationallicence Inoue Makoto Sumitomo Pharmaceuticals Research Center, 1-98, Kasugadenaka 3-chome, Konohana-ku, 554, Osaka, Japan aut Nakayama Chikao Sumitomo Pharmaceuticals Research Center, 1-98, Kasugadenaka 3-chome, Konohana-ku, 554, Osaka, Japan aut Noguchi Hiroshi Sumitomo Pharmaceuticals Research Center, 1-98, Kasugadenaka 3-chome, Konohana-ku, 554, Osaka, Japan aut Molecular Neurobiology Humana Press 12/3(1996-06-01), 195-209 0893-7648 12:3<195 1996 12 12035 https://doi.org/10.1007/BF02755588 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02755588 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Inoue Makoto Sumitomo Pharmaceuticals Research Center, 1-98, Kasugadenaka 3-chome, Konohana-ku, 554, Osaka, Japan aut NATIONALLICENCE 700 1- Nakayama Chikao Sumitomo Pharmaceuticals Research Center, 1-98, Kasugadenaka 3-chome, Konohana-ku, 554, Osaka, Japan aut NATIONALLICENCE 700 1- Noguchi Hiroshi Sumitomo Pharmaceuticals Research Center, 1-98, Kasugadenaka 3-chome, Konohana-ku, 554, Osaka, Japan aut NATIONALLICENCE 773 0- Molecular Neurobiology Humana Press 12/3(1996-06-01), 195-209 0893-7648 12:3<195 1996 12 12035 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer