caa a22 4500 477038255 CHVBK 20180405111310.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/BF02755587 doi (NATIONALLICENCE)springer-10.1007/BF02755587 Lukasiewicz Peter Departments of Ophthalmology & Visual Sciences and of Anatomy & Neurobiology, Washington University School of Medicine, Box 8096, 63110-1093, St. Louis, MO aut GABAC receptors in the vertebrate retina [Elektronische Daten] [Peter Lukasiewicz] In the central nervous system (CNS), the inhibitory transmitter GABA interacts with three subtypes of GABA receptors, type A, type B, and type C. Historically, GABA receptors have been classified as either the inotropic GABAA receptors or the metabotropic GABAB receptors. Over the past 10 yr, studies have shown that a third class, called the GABAC receptor, also exists. GABAC receptors are found primarily in the vertebrate retina and to some extent in other parts of the CNS. Although GABAA and GABAC receptors both gate chloride channels, they are pharmacologically, molecularly, and functionally distinct. The ρ subunit of the GABAC receptor, which has about 35% amino acid homology to GABAA receptor subunits, was cloned from the retina and, when expressed inXenopus oocytes, has properties similar to retinal GABAC receptors. There are probably distinct roles for GABAC receptors in the retina, because they are found on only a subset of neurons, whereas GABAA receptors are ubiquitous. This article reviews recent electrophysiological and molecular studies that have characterized the unique properties of GABAC receptors and describes the roles that these receptors may play in visual information processing in the retina. Humana Press Inc, 1996 GABA nationallicence GABAC receptor nationallicence retina nationallicence ρ1 receptor nationallicence ρ2 receptor nationallicence horizontal cells nationallicence bipolar cells nationallicence bicuculline-insensitive nationallicence Molecular Neurobiology Humana Press 12/3(1996-06-01), 181-194 0893-7648 12:3<181 1996 12 12035 https://doi.org/10.1007/BF02755587 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02755587 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Lukasiewicz Peter Departments of Ophthalmology & Visual Sciences and of Anatomy & Neurobiology, Washington University School of Medicine, Box 8096, 63110-1093, St. Louis, MO aut NATIONALLICENCE 773 0- Molecular Neurobiology Humana Press 12/3(1996-06-01), 181-194 0893-7648 12:3<181 1996 12 12035 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer