caa a22 4500 477038263 CHVBK 20180405111310.0 cr unu---uuuuu 170330e19960401xx s 000 0 eng 10.1007/BF02740650 doi (NATIONALLICENCE)springer-10.1007/BF02740650 Wingate Richard Department of Developmental Neurobiology, Division of Anatomy and Cell Biology, UMDS, Guy's Hospital, London Bridge, SE1 9RT, London, UK aut Retinal ganglion cell dendritic development and its control [Elektronische Daten] Filling the gaps [Richard Wingate] The way in which central neurons acquire their complex and precise dendrite arbors is of considerable developmental interest. Using retinal ganglion cells (RGCs) as a model, the mechanisms that pattern dendritic development are beginning to emerge. As in other systems, final dendrite phenotype is achieved by a mixture of intrinsic and extrinsic determinants. The extrinsic determinants of RGC dendrite shape reflect the anatomical constraints of producing a paracrystalline mosaic of arbors that laminates the inner plexiform layer of the retina. In this article, the key features of RGC dendrite development are reviewed. The emerging molecular mechanisms behind dendritic laminar segregation and "dendritic competition” are described. The role of afferent extrinsic influences are contrasted with those of retrograde, activity-dependent target influences that may regulate the final maturational phase of dendrite remodeling. Humana Press Inc, 1996 Dendritic competition nationallicence inner plexiform layer nationallicence neurogenesis nationallicence TTX nationallicence NMDA nationallicence APV nationallicence APB nationallicence lucifer yellow nationallicence Molecular Neurobiology Humana Press 12/2(1996-04-01), 133-144 0893-7648 12:2<133 1996 12 12035 https://doi.org/10.1007/BF02740650 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02740650 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Wingate Richard Department of Developmental Neurobiology, Division of Anatomy and Cell Biology, UMDS, Guy's Hospital, London Bridge, SE1 9RT, London, UK aut NATIONALLICENCE 773 0- Molecular Neurobiology Humana Press 12/2(1996-04-01), 133-144 0893-7648 12:2<133 1996 12 12035 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer