caa a22 4500 477038271 CHVBK 20180405111310.0 cr unu---uuuuu 170330e19960401xx s 000 0 eng 10.1007/BF02740651 doi (NATIONALLICENCE)springer-10.1007/BF02740651 A composite model for establishing the microtubule arrays of the neuron [Elektronische Daten] [Peter Baas, Wenqian Yu] Neurons generate two distinct types of processes, termed axons and dendrites, both of which rely on a highly organized array of microtubules for their growth and maintenance. Axonal microtubules are uniformly oriented with their plus ends distal to the cell body, whereas dendritic microtubules are nonuniformly oriented. In neither case are the microtubules attached to the centrosome or any detectable structure that could establish their distinct patterns of polarity orientation. Studies from our laboratory over the past few years have led us to propose the following model for the establishment of the axonal and dendritic microtubule arrays. Microtubules destined for these processes are nucleated at the centrosome within the cell body of the neuron and rapidly released. The released microtubules are then transported into developing axons and dendrites to support their growth. Early in neuronal development, the microtubules are transported with their plus ends leading into immature processes that are the common progenitors of both axons and dendrites. This sets up a uniformly plus-end-distal pattern of polarity orientation, which is preserved in the developing axon. In the case of the dendrite, the plus-end-distal microtubules are joined by another population of microtubules that are transported into these processes with their minus-ends leading. Implicit in this model is that neurons have specialized machinery for regulating the release of microtubules from the centrosome and for transporting them with great specificity. Humana Press Inc, 1996 Neuron nationallicence axon nationallicence dendrite nationallicence microtubule nationallicence microtubule polarity nationallicence microtubule transport nationallicence microtubule assembly nationallicence centrosome nationallicence microtubule-associated protein nationallicence Baas Peter Department of Anatomy, The University of Wisconsin Medical School, 1300 University Avenue, 53706, Madison, WI aut Yu Wenqian Department of Anatomy, The University of Wisconsin Medical School, 1300 University Avenue, 53706, Madison, WI aut Molecular Neurobiology Humana Press 12/2(1996-04-01), 145-161 0893-7648 12:2<145 1996 12 12035 https://doi.org/10.1007/BF02740651 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02740651 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Baas Peter Department of Anatomy, The University of Wisconsin Medical School, 1300 University Avenue, 53706, Madison, WI aut NATIONALLICENCE 700 1- Yu Wenqian Department of Anatomy, The University of Wisconsin Medical School, 1300 University Avenue, 53706, Madison, WI aut NATIONALLICENCE 773 0- Molecular Neurobiology Humana Press 12/2(1996-04-01), 145-161 0893-7648 12:2<145 1996 12 12035 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer