caa a22 4500 47703828X CHVBK 20180405111310.0 cr unu---uuuuu 170330e19960401xx s 000 0 eng 10.1007/BF02740652 doi (NATIONALLICENCE)springer-10.1007/BF02740652 Role of Drosophila TRP in inositide-mediated Ca2+ entry [Elektronische Daten] [Baruch Minke, Zvi Selinger] Inositol lipid signaling relies on an InsP3-induced Ca2+ release from intracellular stores and on extracellular Ca2+ entry, which takes place when the Ca2+ stores become depleted of Ca2+. This interplay between Ca2+ release and Ca2+ entry has been termed capacitative Ca2+ entry and the inward current calcium release activated current (CRAC) to indicate gating of Ca2+ entry by Ca2+-store depletion. The signaling pathway and the gating mechanism of capacitative Ca2+ entry, however, are largely unknown and the molecular participants in this process have not been identified. In this article we review genetic, molecular, and functional studies of wild-type and mutantDrosophila photoreceptors, suggesting that thetransient receptor potential mutant (trp) is the first putative capacitative Ca2+ entry mutant. Furthermore, several lines of evidence suggest that thetrp gene product TRP is a candidate subunit of the plasma membrane channel that is activated by Ca2+ store depletion. Humana Press Inc, 1996 Ca2+ mobilization nationallicence genetic dissection nationallicence phototransduction nationallicence inositol lipid signaling nationallicence Minke Baruch Department of Physiology, The Hebrew University, 91120, Jerusalem, Israel aut Selinger Zvi Biological Chemistry, The Hebrew University, 91120, Jerusalem, Israel aut Molecular Neurobiology Humana Press 12/2(1996-04-01), 163-180 0893-7648 12:2<163 1996 12 12035 https://doi.org/10.1007/BF02740652 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02740652 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Minke Baruch Department of Physiology, The Hebrew University, 91120, Jerusalem, Israel aut NATIONALLICENCE 700 1- Selinger Zvi Biological Chemistry, The Hebrew University, 91120, Jerusalem, Israel aut NATIONALLICENCE 773 0- Molecular Neurobiology Humana Press 12/2(1996-04-01), 163-180 0893-7648 12:2<163 1996 12 12035 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer