caa a22 4500 47703831X CHVBK 20180405111310.0 cr unu---uuuuu 170330e19960401xx s 000 0 eng 10.1007/BF02740649 doi (NATIONALLICENCE)springer-10.1007/BF02740649 Elevation of intracellular calcium levels in neurons by nicotinic acetylcholine receptors [Elektronische Daten] [Margaret Rathouz, Sukumar Vijayaraghavan, Darwin Berg] The recognition that intracellular free calcium serves as a ubiquitous intracellular signal has motivated efforts to elucidate mechanisms by which cells regulate calcium influx. One route of entry that may offer both spatial and temporal fine resolution for altering calcium levels is that provided by cation-permeable, ligand-gated ion channels. Biophysical measurements as well as calcium imaging techniques demonstrate that neuronal nicotinic acetylcholine receptors as a class have a high relative permeability to calcium; some subtypes equal or exceed all other known receptors in this respect. Activation of nicotinic receptors on neurons can produce substantial increases in intracellular calcium levels by direct passage of calcium through the receptor channel. When multiple classes of nicotinic receptors are expressed by the same neuron, each appears capable of increasing calcium in the cell but may differ with respect to location, temporal response, agonist sensitivity, or regulation in achieving it. As a result, nicotinic receptors must be considered strong candidates for signaling molecules through which neurons regulate a diverse array of cellular events. Humana Press Inc, 1996 Acetylcholine nationallicence nicotinic receptors nationallicence calcium signaling nationallicence Rathouz Margaret Department of Biology, University of California, San Diego, 92093, La Jolla, CA aut Vijayaraghavan Sukumar Department of Biology, University of California, San Diego, 92093, La Jolla, CA aut Berg Darwin Department of Biology, University of California, San Diego, 92093, La Jolla, CA aut Molecular Neurobiology Humana Press 12/2(1996-04-01), 117-131 0893-7648 12:2<117 1996 12 12035 https://doi.org/10.1007/BF02740649 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02740649 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rathouz Margaret Department of Biology, University of California, San Diego, 92093, La Jolla, CA aut NATIONALLICENCE 700 1- Vijayaraghavan Sukumar Department of Biology, University of California, San Diego, 92093, La Jolla, CA aut NATIONALLICENCE 700 1- Berg Darwin Department of Biology, University of California, San Diego, 92093, La Jolla, CA aut NATIONALLICENCE 773 0- Molecular Neurobiology Humana Press 12/2(1996-04-01), 117-131 0893-7648 12:2<117 1996 12 12035 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer