caa a22 4500 477038352 CHVBK 20180405111310.0 cr unu---uuuuu 170330e19960801xx s 000 0 eng 10.1007/BF02740753 doi (NATIONALLICENCE)springer-10.1007/BF02740753 The modulation of calcium currents by the activation of mGluRs [Elektronische Daten] Functional implications [Alessandro Stefani, Antonio Pisani, Nicola Mercuri, Paolo Calabresi] Glutamatergic transmission in the central nervous system (CNS) is mediated by ionotropic, ligand-gated receptors (iGluRs), and metabotropic receptors (mGluRs). mGluRs are coupled to GTP-binding regulatory proteins (G-proteins) and modulate different second messenger pathways. Multiple effects have been described following their activation; among others, regulation of fast synaptic transmission, changes in synaptic plasticity, and modification of the threshold for seizure generation. Some of the major roles played by the activation of mGluRs might depend on the modulation of high-voltage-activated (HVA) calcium (Ca2+) currents. Some HVA Ca2+ channels (N-, P-, and Q-type channels) are signaling components at most presynaptic active zones. Their mGluR-mediated inhibition reduces synaptic transmission. The interference, by agonists at mGluRs, on L-type channels might affect the repetitive neuronal firing behavior and the integration of complex events at the somatic level. In addition, the mGluR-mediated effects on voltagegated Ca2+ signals have been suggested to strongly influence neurotoxicity. Rather different coupling mechanisms underlie the relation between mGluRs and Ca2+ currents: Together with a fast, membrane-delimited mechanism of action, much slower responses, involving intracellular second messengers, have also been postulated. In the recent past, the relative paucity of selective agonists and antagonists for the different subclasses of mGluRs had hampered the clear definition of the roles of mGluRs in brain function. However, the recent availability of new pharmacological tools is promising to provide a better understanding of the neuronal functions related to different mGluR subtypes. The analysis of the mGluR-mediated modulation of Ca2+ conductances will probably offer new insights into the characterization of synaptic transmission and the development of neuroprotective agents. Humana Press Inc, 1996 HVA Ca2+ conductances nationallicence neurotransmission nationallicence neuroprotection nationallicence rat nationallicence metabotropic receptors nationallicence Stefani Alessandro Clinica Neurologica, Università di Tor Vergata, 00133, Rome aut Pisani Antonio Clinica Neurologica, Università di Tor Vergata, 00133, Rome aut Mercuri Nicola Clinica Neurologica, Università di Tor Vergata, 00133, Rome aut Calabresi Paolo Clinica Neurologica, Università di Tor Vergata, 00133, Rome aut Molecular Neurobiology Humana Press 13/1(1996-08-01), 81-95 0893-7648 13:1<81 1996 13 12035 https://doi.org/10.1007/BF02740753 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02740753 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Stefani Alessandro Clinica Neurologica, Università di Tor Vergata, 00133, Rome aut NATIONALLICENCE 700 1- Pisani Antonio Clinica Neurologica, Università di Tor Vergata, 00133, Rome aut NATIONALLICENCE 700 1- Mercuri Nicola Clinica Neurologica, Università di Tor Vergata, 00133, Rome aut NATIONALLICENCE 700 1- Calabresi Paolo Clinica Neurologica, Università di Tor Vergata, 00133, Rome aut NATIONALLICENCE 773 0- Molecular Neurobiology Humana Press 13/1(1996-08-01), 81-95 0893-7648 13:1<81 1996 13 12035 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer