caa a22 4500 477038409 CHVBK 20180405111310.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/BF02740622 doi (NATIONALLICENCE)springer-10.1007/BF02740622 Functional roles of neurotrophin 3 in the developing and mature sympathetic nervous system [Elektronische Daten] [Xin-Fu Zhou, Robert Rush] Nerve growth factor (NGF) is a potent regulator of sympathetic neuronal function in both developing and adult animals. This article reviews the evidence published in recent years indicating that another member of the NGF family, neurotrophin 3 (NT3), plays both a complementary and overlapping role in the development and maturation of sympathetic neurons. In migratory neural crest cells, expression of the high-affinity receptor, trkC, and promotion of mitosis by NT3 suggest an involvement in gangliogenesis, since sympathetic neuroblasts express both NT3 and trkC and require NT3 for their proliferation, differentiation, and survival, it has been proposed that the factor acts at this developmental stage as an autocrine or paracrine factor. However, NT3 also acts in parallel with NGF to promote the survival of postmitotic neurons during late development. Both trkC and trkA are expressed in sympathetic neurons and function as high-affinity receptors for NT3. NT3 is synthesized in sympathetic effector tissues and the endogenous factor is retrogradely transported to accumulate within the cell soma. Thus, in addition to its role in the differentiation of sympathetic neurons, NT3, like NGF, is also an effector tissue-derived neurotrophic factor for these neurons in maturity. Humana Press Inc, 1996 Neurotrophin nationallicence sympathetic neurons nationallicence development nationallicence neurotrophic factors nationallicence trk nationallicence differentiation nationallicence Zhou Xin-Fu Department of Human Physiology and Centre for Neuroscience, Flinders University of South Australia, PO Box 2100, Adelaide, Australia aut Rush Robert Department of Human Physiology and Centre for Neuroscience, Flinders University of South Australia, PO Box 2100, Adelaide, Australia aut Molecular Neurobiology Humana Press 13/3(1996-12-01), 185-197 0893-7648 13:3<185 1996 13 12035 https://doi.org/10.1007/BF02740622 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02740622 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhou Xin-Fu Department of Human Physiology and Centre for Neuroscience, Flinders University of South Australia, PO Box 2100, Adelaide, Australia aut NATIONALLICENCE 700 1- Rush Robert Department of Human Physiology and Centre for Neuroscience, Flinders University of South Australia, PO Box 2100, Adelaide, Australia aut NATIONALLICENCE 773 0- Molecular Neurobiology Humana Press 13/3(1996-12-01), 185-197 0893-7648 13:3<185 1996 13 12035 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer