caa a22 4500 47703845X CHVBK 20180405111310.0 cr unu---uuuuu 170330e19961001xx s 000 0 eng 10.1007/BF02740639 doi (NATIONALLICENCE)springer-10.1007/BF02740639 The early intracellular signaling pathway for the insulin/insulin-like growth factor receptor family in the mammalian central nervous system [Elektronische Daten] [Franco Folli, Silvana Ghidella, Luca Bonfanti, C. Kahn, Adalberto Merighi] Several studies support the idea that the polypeptides belonging to the family of insulin and insulin-like growth factors (IGFs) play an important role in brain development and continue to be produced in discrete areas of the adult brain. In numerous neuronal populations within the olfactory bulb, the cerebral and cerebellar cortex, the hippocampus, some diencephalic and brainstem nuclei, the spinal cord and the retina, specific insulin and IGF receptors, as well as crucial components of the intracellular receptor signaling pathway have been demonstrated. Thus, mature neurons are endowed with the cellular machinery to respond to insulin and IGF stimulation. Studies in vitro and in vivo, using normal and transgenic animals, have led to the hypothesis that, in the adult brain, IGF-I not only acts as a trophic factor, but also as a neuromodulator of some higher brain functions, such as long-term potentiation and depression. Furthermore, a trophic effect on certain neuronal populations becomes clearly evident in the ischemic brain or neurodegenerative disorders. Thus, the analysis of the early intracellular signaling pathway for the insulin/IGF receptor family in the brain is providing us with new intriguing findings on the way the mammalian brain is sculpted and operates. Humana Press Inc, 1996 Insulin nationallicence IGF-I nationallicence IGF-II nationallicence IGF receptor nationallicence IRS-1 nationallicence IRS-2 nationallicence PI-3 kinase nationallicence neurons nationallicence glial cells nationallicence central nervous system nationallicence Folli Franco Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, 02115, Boston, MA aut Ghidella Silvana Dipartimento di Morfofisiologia Veterinaria, Università degli Studi di Torino, Via Nizza 52, 1-10126, Torino, Italy aut Bonfanti Luca Dipartimento di Morfofisiologia Veterinaria, Università degli Studi di Torino, Via Nizza 52, 1-10126, Torino, Italy aut Kahn C. Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, 02115, Boston, MA aut Merighi Adalberto Dipartimento di Morfofisiologia Veterinaria, Università degli Studi di Torino, Via Nizza 52, 1-10126, Torino, Italy aut Molecular Neurobiology Humana Press 13/2(1996-10-01), 155-183 0893-7648 13:2<155 1996 13 12035 https://doi.org/10.1007/BF02740639 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02740639 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Folli Franco Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, 02115, Boston, MA aut NATIONALLICENCE 700 1- Ghidella Silvana Dipartimento di Morfofisiologia Veterinaria, Università degli Studi di Torino, Via Nizza 52, 1-10126, Torino, Italy aut NATIONALLICENCE 700 1- Bonfanti Luca Dipartimento di Morfofisiologia Veterinaria, Università degli Studi di Torino, Via Nizza 52, 1-10126, Torino, Italy aut NATIONALLICENCE 700 1- Kahn C. Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, 02115, Boston, MA aut NATIONALLICENCE 700 1- Merighi Adalberto Dipartimento di Morfofisiologia Veterinaria, Università degli Studi di Torino, Via Nizza 52, 1-10126, Torino, Italy aut NATIONALLICENCE 773 0- Molecular Neurobiology Humana Press 13/2(1996-10-01), 155-183 0893-7648 13:2<155 1996 13 12035 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer