caa a22 4500 477045332 CHVBK 20180405111328.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/BF01895096 doi (NATIONALLICENCE)springer-10.1007/BF01895096 Morphology and neuropathology of the pelvic floor in patients with stress incontinence [Elektronische Daten] [R. Morley, J. Cumming, R. Weller] Urinary incontinence imposes a considerable workload on urological and gynecological practice. Many treatments exist, but recurrent stress incontinence remains a significant problem and the reasons remain unclear. Pathological and electrophysiological studies have shown that significant pelvic nerve damage and consequent denervation and reinnervation are associated with stress incontinence, and furthermore there are collagenous changes in the pelvic floor which are related to childbirth, endogenous hormone changes and the effects of increasing age. These changes include increased nerve fiber density and pudendal nerve terminal motor latency, hypertrophy of fiber types 1 and 2, type 1 fiber predominance and fiber type grouping. Connective tissue changes involve a reduction in hydroxyproline excretion, increased cross-linking and increased muscle collagen. It is only through a better understanding of the anatomy and pathophysiology of the pelvic floor that we will be able to improve outcome in women with stress incontinence and identify patients that may not be appropriate for surgical therapy. This paper reviews recent advances in the understanding of the etiology of stress incontinence. The International Urogynecology Journal, 1996 Atrophy nationallicence Collagen nationallicence Fiber types nationallicence Hypertrophy nationallicence Neuropathy nationallicence Levator ani nationallicence Morley R. Department of Urology, Southampton University Hospital, Tremona Rd., Southampton, UK aut Cumming J. Department of Urology, Southampton University Hospital, Tremona Rd., Southampton, UK aut Weller R. Department of Urology, Southampton University Hospital, Tremona Rd., Southampton, UK aut International Urogynecology Journal Springer-Verlag 7/1(1996-01-01), 3-12 0937-3462 7:1<3 1996 7 192 https://doi.org/10.1007/BF01895096 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01895096 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Morley R. Department of Urology, Southampton University Hospital, Tremona Rd., Southampton, UK aut NATIONALLICENCE 700 1- Cumming J. Department of Urology, Southampton University Hospital, Tremona Rd., Southampton, UK aut NATIONALLICENCE 700 1- Weller R. Department of Urology, Southampton University Hospital, Tremona Rd., Southampton, UK aut NATIONALLICENCE 773 0- International Urogynecology Journal Springer-Verlag 7/1(1996-01-01), 3-12 0937-3462 7:1<3 1996 7 192 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer