caa a22 4500 477045391 CHVBK 20180405111329.0 cr unu---uuuuu 170330e19961101xx s 000 0 eng 10.1007/BF01901108 doi (NATIONALLICENCE)springer-10.1007/BF01901108 Direct effect of amezinium on rabbit urethra: Effect of estrogen and progesterone treatment [Elektronische Daten] [M. Ishigooka, T. Hashimoto, Y. Suzuki, O. Ichiyanagi, I. Sasagawa, T. Nakada] The effect of amezinium, a new antihypotensive agent, and hormonal treatment on the female rabbit urethra was investigated. Cumulative dose responses were obtained for amezinium and norepinephrine on strips of muscle from the urethras of ovariectomized female rabbits by means of the tissuebath system. Amezinium enhanced the response to electrical field stimulation and showed a direct contractile response on the urethra. These responses were only about 20% of the maximum norepinephrine response. The contractile response to amezinium was completely blocked by prazosin. When rabbits were pretreated with estrogen, with or without progesterone, for 4 weeks, the response to amezinium increased to 40% of the maximum norepinephrine response. Although amezinium enhances muscle contractile responses to electrical stimulation, this effect is strong when amezinium is used alone; concurrent estrogen treatment improves the effects of amezinium. The International Urogynecology Journal, 1996 Amezinium nationallicence Estrogen nationallicence Progesterone nationallicence Rabbit urethra nationallicence Ishigooka M. Department of Urology, Yamagata University School of Medicine, 2-2-2 Lida Nishi, 990-23, Yamagata, Japan aut Hashimoto T. Department of Urology, Yamagata University School of Medicine, 2-2-2 Lida Nishi, 990-23, Yamagata, Japan aut Suzuki Y. Department of Urology, Yamagata University School of Medicine, 2-2-2 Lida Nishi, 990-23, Yamagata, Japan aut Ichiyanagi O. Department of Urology, Yamagata University School of Medicine, 2-2-2 Lida Nishi, 990-23, Yamagata, Japan aut Sasagawa I. Department of Urology, Yamagata University School of Medicine, 2-2-2 Lida Nishi, 990-23, Yamagata, Japan aut Nakada T. Department of Urology, Yamagata University School of Medicine, 2-2-2 Lida Nishi, 990-23, Yamagata, Japan aut International Urogynecology Journal Springer-Verlag 7/6(1996-11-01), 325-330 0937-3462 7:6<325 1996 7 192 https://doi.org/10.1007/BF01901108 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01901108 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ishigooka M. Department of Urology, Yamagata University School of Medicine, 2-2-2 Lida Nishi, 990-23, Yamagata, Japan aut NATIONALLICENCE 700 1- Hashimoto T. Department of Urology, Yamagata University School of Medicine, 2-2-2 Lida Nishi, 990-23, Yamagata, Japan aut NATIONALLICENCE 700 1- Suzuki Y. Department of Urology, Yamagata University School of Medicine, 2-2-2 Lida Nishi, 990-23, Yamagata, Japan aut NATIONALLICENCE 700 1- Ichiyanagi O. Department of Urology, Yamagata University School of Medicine, 2-2-2 Lida Nishi, 990-23, Yamagata, Japan aut NATIONALLICENCE 700 1- Sasagawa I. Department of Urology, Yamagata University School of Medicine, 2-2-2 Lida Nishi, 990-23, Yamagata, Japan aut NATIONALLICENCE 700 1- Nakada T. Department of Urology, Yamagata University School of Medicine, 2-2-2 Lida Nishi, 990-23, Yamagata, Japan aut NATIONALLICENCE 773 0- International Urogynecology Journal Springer-Verlag 7/6(1996-11-01), 325-330 0937-3462 7:6<325 1996 7 192 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer