caa a22 4500 477045782 CHVBK 20180405111330.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF01901246 doi (NATIONALLICENCE)springer-10.1007/BF01901246 Hohlbrugger G. Department of Urology, University of Innsbruck, Innsbruck, Austria aut Leaky urothelium and/or vesical ischemia enable urinary potassium to cause idiopathic urgency/frequency syndrome and urge incontinence [Elektronische Daten] [G. Hohlbrugger] Urine contains up to 10 times more potassium (K+) than blood plasma. Hence, extracellular K+ concentration of the bladder wall can increase secondary to a leaky urothelium (GAG layer deficiency) and/or vesical ischemia (reduced washout) at low filling volumes. Consequent sensory afferentiated excitation/depolarization of the detrusor leads to urgency/frequency and facilitates the onset of ‘uninhibited' contractions. This feature, in association with a weak rhabdosphincter, causes urge incontinence. The nonneuromuscular (non-reflexive) origin explains refractoriness to any neurotransmitted inhibition. Even successful interference with contractility (Ca2+) leaves depolarization unaffected. Accordingly, comparative cystometry (saline versus 0.2 M KCl) is recommended in order to comprise better former falsely underdiagnosed ‘normals' as well as former undiscovered urge incontinence, and thus indications for bladder neck surgery as well as neuromuscular drug treatment. Future first-line therapy in idiopathic storage disorders should be directed to the GAG layer, vesical blood flow (K+ washout) and the rhabdosphincter. The International Urogynecology Journal, 1996 Idiopathic urgency/frequency nationallicence Urinary potassium nationallicence International Urogynecology Journal Springer-Verlag 7/5(1996-09-01), 242-255 0937-3462 7:5<242 1996 7 192 https://doi.org/10.1007/BF01901246 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01901246 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Hohlbrugger G. Department of Urology, University of Innsbruck, Innsbruck, Austria aut NATIONALLICENCE 773 0- International Urogynecology Journal Springer-Verlag 7/5(1996-09-01), 242-255 0937-3462 7:5<242 1996 7 192 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer