caa a22 4500 477045871 CHVBK 20180405111330.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF01902379 doi (NATIONALLICENCE)springer-10.1007/BF01902379 The effect of urethral pressure variation on detrusor activity in women [Elektronische Daten] [S. Farrell, G. Tynski] The purposes of this study were to confirm previously described patterns of urethral pressure variation and to establish criteria for their diagnosis. The effect of urethral pressure variation on detrusor activity was also examined. The study involved a retrospective review of the computerized cystometric tracings from a 26-month period. Forty-one patients had artefact-free satisfactory tracings demonstrating urethral pressure variation, detrusor instability and/or gradual detrusor pressure increase. These tracings were stored on a computer program which permitted real-time second-by-second review. Statistical analysis was done using Fisher's exact test and an independentt-test. Three patterns of urethral pressure variation were identified: rapid pressure variation (RPV), gradual pressure variation (GPV) and stress-induced transient urethral relaxation (SITUR). RPV was associated with onset at low bladder volumes (independentt-test,P=0.02) and with detrusor instability (Fisher's exact test,P<0.001). GPV began at high bladder volumes (Fisher's exact test,P<0.001). SITUR was not associated with any specific pattern of urethral pressure variation or detrusor pressure change. Analysis of tracings of the patients with a combination of rapid urethral pressure variation and detrusor instability revealed a statistically significant increased frequency of urethral relaxation as the primary event precipitating an unstable detrusor contraction (Fisher's exact test,P<0.003). In conclusion, three different patterns of urethral pressure variation were identified. Rapid pattern urethral pressure variation is closely associated with detrusor instability. Further study of urethral pressure variation may help to elucidate the pathophysiologic mechanism responsible for idiopathic unstable detrusor contractions. The International Urogynecology Journal, 1996 Detrusor instability nationallicence urethral pressure variation nationallicence Farrell S. Department of Obstetrics and Gynecology, Dalhousie University, Halifax, Nova Scotia, Canada aut Tynski G. Department of Obstetrics and Gynecology, Dalhousie University, Halifax, Nova Scotia, Canada aut International Urogynecology Journal Springer-Verlag 7/2(1996-03-01), 87-93 0937-3462 7:2<87 1996 7 192 https://doi.org/10.1007/BF01902379 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01902379 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Farrell S. Department of Obstetrics and Gynecology, Dalhousie University, Halifax, Nova Scotia, Canada aut NATIONALLICENCE 700 1- Tynski G. Department of Obstetrics and Gynecology, Dalhousie University, Halifax, Nova Scotia, Canada aut NATIONALLICENCE 773 0- International Urogynecology Journal Springer-Verlag 7/2(1996-03-01), 87-93 0937-3462 7:2<87 1996 7 192 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer