caa a22 4500 477054064 CHVBK 20180405111344.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF02644768 doi (NATIONALLICENCE)springer-10.1007/BF02644768 Negative regulators of the interleukin-1 system: receptor antagonists and a decoy receptor [Elektronische Daten] [A. Mantovani, M. Muzio, P. Ghezzi, F. Colotta, M. Introna] The IL-1 system includes 2 agonists, α and β, processing and transport molecules, receptor antagonists, signalling receptor, a decoy receptor and an accessory molecule. Negative pathways of regulation include the antagonists, of which 3 isoforms have been cloned and the type II "decoy” receptor. Molecules that regulate inflammation and immunity coordinatively affect different components of the system. The complexity of the system and the existence of unique pathways of negative regulation, the antagonists and the decoy receptor, emphasize the need for a tight control of the production and action of IL-1. Springer-Verlag, 1996 IL-1 nationallicence Receptors nationallicence Antagonists nationallicence Inflammation nationallicence Immunity nationallicence Mantovani A. Istituto di Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut Muzio M. Istituto di Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut Ghezzi P. Istituto di Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut Colotta F. Department of Immunology and Microbiology, Pharmacia Research Center, Nerviano, Milan, Italy aut Introna M. Istituto di Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut International Journal of Clinical and Laboratory Research Springer-Verlag 26/1(1996-03-01), 7-14 0940-5437 26:1<7 1996 26 599 https://doi.org/10.1007/BF02644768 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02644768 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mantovani A. Istituto di Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut NATIONALLICENCE 700 1- Muzio M. Istituto di Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut NATIONALLICENCE 700 1- Ghezzi P. Istituto di Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut NATIONALLICENCE 700 1- Colotta F. Department of Immunology and Microbiology, Pharmacia Research Center, Nerviano, Milan, Italy aut NATIONALLICENCE 700 1- Introna M. Istituto di Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut NATIONALLICENCE 773 0- International Journal of Clinical and Laboratory Research Springer-Verlag 26/1(1996-03-01), 7-14 0940-5437 26:1<7 1996 26 599 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer