caa a22 4500 477054153 CHVBK 20180405111344.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF02644777 doi (NATIONALLICENCE)springer-10.1007/BF02644777 Antibody response to islet antigens in anti-CD4/prednisolone immune intervention of type 1 diabetes [Elektronische Daten] [K. Kohnert, B. Hehmke, H. Keilacker, M. Ziegler, F. Emmrich, F. Laube, D. Michaelis] Cytoplasmic islet cell antibodies, glutamic acid decarboxylase autoantibodies, spontaneous insulin autoantibodies, and insulin-induced antibodies were analyzed in a 1-year follow-up study of 12 newly diagnosed patients with insulin-dependent diabetes mellitus aged 14±2 years (range 7-20 years) who had been initially treated with either multiple injections of insulin alone (control group) or, in addition, anti-CD4 monoclonal antibody/prednisolone (treatment group). Despite individual variations in islet cell antibody titers, there were no significant differences in the prevalence or changes in the mean titers between the two groups. Glutamic acid decarboxylase autoantibodies remained almost unchanged, but correlated with levels of islet cell antibodies. While at initiation of treatment only 50% of the patients from both groups had spontaneous insulin autoantibodies, all patients developed insulin-induced antibodies upon conventional insulin therapy during the course of follow-up. This was not related to islet cell antibody or glutamic acid decarboxylase antibody levels. The insulin requirement was markedly reduced through the period of follow-up, but did not significantly differ between the two groups. A correlation between islet cell antibody levels and insulin requirement was observed in the control group but not in the treatment group. Plasma levels of the antibodies were not associated with changes in stimulated C-peptide or hemoglobin A1 concentrations. Activated T-lymphocytes persisted in both groups of patients, but their mean levels were not significantly different. The reason for the absence of statistically significant differences between treatment and control groups could be due to the small number of patients in the study. In conclusion, short-term immune intervention with anti-CD4 monoclonal antibody in addition to insulin therapy did not suppress autoimmune reactions towards the beta cells. Springer-Verlag, 1996 Islet cell antibodies nationallicence Glutamic acid decarboxylase autoantibodies nationallicence Insulin (auto) antibodies nationallicence Anti-CD4 therapy nationallicence Type I diabetes nationallicence Kohnert K. Institute of Diabetes "Gerhardt Katsch”, University of Greifswald, Greifswalder Strasse 11a, D-17495, Karlsburg, Germany aut Hehmke B. Institute of Diabetes "Gerhardt Katsch”, University of Greifswald, Greifswalder Strasse 11a, D-17495, Karlsburg, Germany aut Keilacker H. Institute of Diabetes "Gerhardt Katsch”, University of Greifswald, Greifswalder Strasse 11a, D-17495, Karlsburg, Germany aut Ziegler M. Institute of Clinical Immunology and Transfusion Medicine, University of Leipzig, Germany aut Emmrich F. Institute of Clinical Immunology and Transfusion Medicine, University of Leipzig, Germany aut Laube F. Community Hospital Wolgast, Germany aut Michaelis D. Centre of Diabetes and Metabolic Diseases, Karlsburg, Germany aut International Journal of Clinical and Laboratory Research Springer-Verlag 26/1(1996-03-01), 55-59 0940-5437 26:1<55 1996 26 599 https://doi.org/10.1007/BF02644777 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02644777 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kohnert K. Institute of Diabetes "Gerhardt Katsch”, University of Greifswald, Greifswalder Strasse 11a, D-17495, Karlsburg, Germany aut NATIONALLICENCE 700 1- Hehmke B. Institute of Diabetes "Gerhardt Katsch”, University of Greifswald, Greifswalder Strasse 11a, D-17495, Karlsburg, Germany aut NATIONALLICENCE 700 1- Keilacker H. Institute of Diabetes "Gerhardt Katsch”, University of Greifswald, Greifswalder Strasse 11a, D-17495, Karlsburg, Germany aut NATIONALLICENCE 700 1- Ziegler M. Institute of Clinical Immunology and Transfusion Medicine, University of Leipzig, Germany aut NATIONALLICENCE 700 1- Emmrich F. Institute of Clinical Immunology and Transfusion Medicine, University of Leipzig, Germany aut NATIONALLICENCE 700 1- Laube F. Community Hospital Wolgast, Germany aut NATIONALLICENCE 700 1- Michaelis D. Centre of Diabetes and Metabolic Diseases, Karlsburg, Germany aut NATIONALLICENCE 773 0- International Journal of Clinical and Laboratory Research Springer-Verlag 26/1(1996-03-01), 55-59 0940-5437 26:1<55 1996 26 599 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer