caa a22 4500 477054196 CHVBK 20180405111344.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF02644770 doi (NATIONALLICENCE)springer-10.1007/BF02644770 Regulation of hematopoietic cell proliferation and differentiation by the myb oncogene family of transcription factors [Elektronische Daten] [J. Golay, L. Basilico, L. Loffarelli, S. Songia, V. Broccoli, M. Introna] Themyb family of genes include the virally encoded v-myb oncogene, its normal cellular equivalent c-myb and two related members called A-myb and B-myb. They are all transcription factors that recognize the same DNA sequence (PyAACG/TG) and are all involved in the regulation of proliferation and differentiation in different cell types, including hematopoietic cells. C-myb is most highly expressed in hematopoietic cells and its oncogenic activation leads to transformation of these cells. Several lines of evidence have demonstrated that c-myb regulates both the proliferation and differentiation of hematopoietic cells of different lineages. The mechanisms of action of c-myb and v-myb are becoming clearer, mostly through the study of the different genes that are regulated by these transcription factors and the cofactors with which c-myb and v-myb co-operate. More recently the biological and biochemical functions of the B-myb and A-myb gene products have been investigated. Evidence for the function of the different members of themyb family in relation to hematopoietic proliferation and differentiation is presented, and the different roles of themyb genes are discussed. Springer-Verlag, 1996 Myb nationallicence Hematopoietic nationallicence Proliferation nationallicence Differentiation nationallicence Transcription factor nationallicence Golay J. Laboratory of Molecular Immunohematology, Department of Immunology and Cell Biology, Istituto Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut Basilico L. Laboratory of Molecular Immunohematology, Department of Immunology and Cell Biology, Istituto Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut Loffarelli L. Laboratory of Molecular Immunohematology, Department of Immunology and Cell Biology, Istituto Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut Songia S. Laboratory of Molecular Immunohematology, Department of Immunology and Cell Biology, Istituto Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut Broccoli V. Laboratory of Molecular Immunohematology, Department of Immunology and Cell Biology, Istituto Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut Introna M. Laboratory of Molecular Immunohematology, Department of Immunology and Cell Biology, Istituto Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut International Journal of Clinical and Laboratory Research Springer-Verlag 26/1(1996-03-01), 24-32 0940-5437 26:1<24 1996 26 599 https://doi.org/10.1007/BF02644770 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02644770 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Golay J. Laboratory of Molecular Immunohematology, Department of Immunology and Cell Biology, Istituto Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut NATIONALLICENCE 700 1- Basilico L. Laboratory of Molecular Immunohematology, Department of Immunology and Cell Biology, Istituto Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut NATIONALLICENCE 700 1- Loffarelli L. Laboratory of Molecular Immunohematology, Department of Immunology and Cell Biology, Istituto Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut NATIONALLICENCE 700 1- Songia S. Laboratory of Molecular Immunohematology, Department of Immunology and Cell Biology, Istituto Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut NATIONALLICENCE 700 1- Broccoli V. Laboratory of Molecular Immunohematology, Department of Immunology and Cell Biology, Istituto Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut NATIONALLICENCE 700 1- Introna M. Laboratory of Molecular Immunohematology, Department of Immunology and Cell Biology, Istituto Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut NATIONALLICENCE 773 0- International Journal of Clinical and Laboratory Research Springer-Verlag 26/1(1996-03-01), 24-32 0940-5437 26:1<24 1996 26 599 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer