caa a22 4500 477054226 CHVBK 20180405111344.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF02644773 doi (NATIONALLICENCE)springer-10.1007/BF02644773 Lipoprotein(a) is not elevated in non-diabetic microalbuminuric subjects [Elektronische Daten] A longitudinal study of lipoprotein(a) concentrations and apolipoprotein(a) size isoforms [J. Yudkin, S. Marcovina, W. Foyle, M. Fernandez] Microalbuminuric non-diabetic subjects have an increased risk of cardiovascular disease which is not explained by standard risk factors. In diabetic patients, microalbuminuria is associated with increased lipoprotein(a) concentrations. We have determined lipoprotein(a) concentrations and duplicate measures of albumin excretion rate, on two occasions separated by around 3 years, in 125 Europid subjects aged 40-75 years without hypertension or glucose intolerance and in 49 offspring aged 15-40 years. The apolipoprotein(a) isoform size, the major genetic determinant of lipoprotein(a) concentration, was also determined. There were no differences in lipoprotein(a) concentration between the 42 subjects who were microalbuminuric on either or both samples at screening (median 9.4 mg/dl, 20th and 80th percentiles 2.6 and 46.3 mg/dl) and the 79 who had been normoalbuminuric at both collections (median 10.9 mg/dl, 20th and 80th percentiles 2.9 and 53.0 mg/dl;P=0.58). Lipoprotein(a) concentrations were not significantly different between subjects with or without microalbuminuria at recell (P=0.55) or between those with or without microalbuminuria classified by mean albumin excretion rate in either collection (P=0.24 andP=0.73, respectively). There were no significant relationships between albumin excretion rate as a continuous variable and lipoprotein(a) concentration, or between changes in the two variables over 3 years. The microalbuminuric and normoalbuminuric subjects had similar distributions of size isoforms. There were also no differences in lipoprotein(a) concentration or isoform distribution between offspring of microalbuminuric and of normoalbuminuric subjects. In conclusion, we found no evidence that micro-albuminuric subjects with normal blood pressure and normal glucose tolerance have elevated concentrations of lipoprotein(a) to explain their increased cardiovascular risk. Springer-Verlag, 1996 Lipoprotein(a) concentration nationallicence Apolipoprotein(a) size isoforms nationallicence Microalbuminuria nationallicence Cardiovascular risk nationallicence Yudkin J. Department of Medicine, University College London Medical School, G Block, Archway Wing, Whittington Hospital, Archway Road, N19 3UA, London, UK aut Marcovina S. Department of Medicine, Northwest Lipid Research Laboratories, University of Washington, Seattle, Washington, USA aut Foyle W. Department of Medicine, University College London Medical School, G Block, Archway Wing, Whittington Hospital, Archway Road, N19 3UA, London, UK aut Fernandez M. Department of Medicine, University College London Medical School, G Block, Archway Wing, Whittington Hospital, Archway Road, N19 3UA, London, UK aut International Journal of Clinical and Laboratory Research Springer-Verlag 26/1(1996-03-01), 43-50 0940-5437 26:1<43 1996 26 599 https://doi.org/10.1007/BF02644773 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02644773 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yudkin J. Department of Medicine, University College London Medical School, G Block, Archway Wing, Whittington Hospital, Archway Road, N19 3UA, London, UK aut NATIONALLICENCE 700 1- Marcovina S. Department of Medicine, Northwest Lipid Research Laboratories, University of Washington, Seattle, Washington, USA aut NATIONALLICENCE 700 1- Foyle W. Department of Medicine, University College London Medical School, G Block, Archway Wing, Whittington Hospital, Archway Road, N19 3UA, London, UK aut NATIONALLICENCE 700 1- Fernandez M. Department of Medicine, University College London Medical School, G Block, Archway Wing, Whittington Hospital, Archway Road, N19 3UA, London, UK aut NATIONALLICENCE 773 0- International Journal of Clinical and Laboratory Research Springer-Verlag 26/1(1996-03-01), 43-50 0940-5437 26:1<43 1996 26 599 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer