caa a22 4500 477054323 CHVBK 20180405111344.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF02592978 doi (NATIONALLICENCE)springer-10.1007/BF02592978 Neutrophil activation by adhesion: mechanisms and pathophysiological implications [Elektronische Daten] [G. Berton, S. Yan, L. Fumagalli, C. Lowell] Neutrophil adhesion plays an essential role in the formation of an inflammatory exudate. Moreover, adhesion activates selective neutrophil functions and regulates the cell response to additional stimuli. In this review we summarize the information available on adhesion molecules involved in neutrophil adhesion to endothelial cells and extracellular matrix proteins and the experimental approaches which have been developed to block neutrophil adhesion and neutrophil mediated tissue damage. We also address the mechanisms of activation of selective neutrophil functions by adhesion molecules and, in particular, the mechanisms of signal transduction by neutrophil integrins. On the basis of recent results obtained in our and other laboratories we propose a model hypothesizing mechanisms of signaling by neutrophil integrins involved in regulation of selective functions. Springer-Verlag, 1996 Neutrophil nationallicence Adhesion nationallicence Signaling nationallicence Selectins nationallicence Integrins nationallicence Tyrosine kinases nationallicence Fgr nationallicence Hck nationallicence Lyn nationallicence Cytoskeleton nationallicence Gene knockout nationallicence Inflammation nationallicence Endothelial cell nationallicence Berton G. Institute of General Pathology, University of Verona, I-37134, Verona, Italy aut Yan S. Institute of General Pathology, University of Verona, I-37134, Verona, Italy aut Fumagalli L. Institute of General Pathology, University of Verona, I-37134, Verona, Italy aut Lowell C. Department of Laboratory Medicine, University of California, San Francisco, USA aut International Journal of Clinical and Laboratory Research Springer-Verlag 26/3(1996-09-01), 160-177 0940-5437 26:3<160 1996 26 599 https://doi.org/10.1007/BF02592978 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02592978 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Berton G. Institute of General Pathology, University of Verona, I-37134, Verona, Italy aut NATIONALLICENCE 700 1- Yan S. Institute of General Pathology, University of Verona, I-37134, Verona, Italy aut NATIONALLICENCE 700 1- Fumagalli L. Institute of General Pathology, University of Verona, I-37134, Verona, Italy aut NATIONALLICENCE 700 1- Lowell C. Department of Laboratory Medicine, University of California, San Francisco, USA aut NATIONALLICENCE 773 0- International Journal of Clinical and Laboratory Research Springer-Verlag 26/3(1996-09-01), 160-177 0940-5437 26:3<160 1996 26 599 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer