caa a22 4500 477054358 CHVBK 20180405111344.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF02592982 doi (NATIONALLICENCE)springer-10.1007/BF02592982 Erythropoietin and uremic platelet aggregation in vivo and in vitro [Elektronische Daten] [J. Malyszko, J. Malyszko, K. Pawlak, M. Mysliwiec] Erythropoietin treatment is known to correct anemia and to improve hemostasis. Since platelets may contribute to thromboembolic complications, we assessed platelet aggregation in whole blood and platelet-rich plasma from chronically hemodialyzed patients treated with erythropoietin and evaluated in vitro effects of this drug on aggregatory responses of uremic and normal platelets. Recombinant human erythropoietin was given to uremic patients at a dose of 2.000 IU subcutaneously three times a week. Platelet aggregation in whole blood and platelet-rich plasma was induced by collagen, ADP, arachidonic acid, and ristocetin. In uremic patients, erythropoietin therapy resulted in an enhancement of platelet sensitivity to various agonists, particularly in platelet-rich plasma, reaching values comparable to those of healthy volunteers. In vitro studies we were unable to show any direct effect of erythropoietin, used at concentrations that occurred post intravenous administration, on platelet aggregation both in whole blood and in platelet-rich plasma. Springer-Verlag, 1996 Uremia nationallicence Erythropoietin nationallicence Platelet aggregation nationallicence Malyszko J. Nephrology Department, Bialystok Medical School, Zurawia 14, 15-540, Bialystok, Poland aut Pawlak K. Nephrology Department, Bialystok Medical School, Zurawia 14, 15-540, Bialystok, Poland aut Mysliwiec M. Nephrology Department, Bialystok Medical School, Zurawia 14, 15-540, Bialystok, Poland aut International Journal of Clinical and Laboratory Research Springer-Verlag 26/3(1996-09-01), 199-202 0940-5437 26:3<199 1996 26 599 https://doi.org/10.1007/BF02592982 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02592982 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Malyszko J. Nephrology Department, Bialystok Medical School, Zurawia 14, 15-540, Bialystok, Poland aut NATIONALLICENCE 700 1- Pawlak K. Nephrology Department, Bialystok Medical School, Zurawia 14, 15-540, Bialystok, Poland aut NATIONALLICENCE 700 1- Mysliwiec M. Nephrology Department, Bialystok Medical School, Zurawia 14, 15-540, Bialystok, Poland aut NATIONALLICENCE 773 0- International Journal of Clinical and Laboratory Research Springer-Verlag 26/3(1996-09-01), 199-202 0940-5437 26:3<199 1996 26 599 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer