caa a22 4500 477054374 CHVBK 20180405111344.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF02592984 doi (NATIONALLICENCE)springer-10.1007/BF02592984 Helicobacter pylori infection enhances mucosal interleukin-1β, interleukin-6, and the soluble receptor of interleukin-2 [Elektronische Daten] [D. Basso, M. Scrigner, A. Toma, F. Navaglia, F. Di Mario, M. Rugge, M. Plebani] It is thought thatHelicobacter pylori colonization of the gastric mucosa might stimulate the production of several cytokines, which might trigger and maintain the gastric inflammation associated withHelicobacter pylori infection. In the present study we evaluated interleukin-1β, interleukin-6, and the soluble receptor of interleukin-2 both in mucosal homogenates and in the sera ofHelicobacter pylori-infected (39 cases) and uninfected (40 cases) patients to investigate whether there was any relationship between variations in cytokines and (1) the severity ofHelicobacter pylori-associated gastritis or (2) CagA-positiveHelicobacter pylori strains. Mucosal, but not serum levels of interleukins-1 and-6 and interleukin-2 receptor were significantly higher in infected than uninfected patients, Serum levels ofHelicobacter pylori antibodies were significantly higher in infected than uninfected patients, These levels correlated with mucosal interleukin-1β. The degree of antral or body inflammatory grade was higher in infected than in uninfected patients; cytokines levels were higher in patients with high-grade gastritis, most of whom wereHelicobacter pylori positive. Patients infected with CagA-positive strains also had higher levels of interleukin-1β, but not of interleukin-2 receptor or interleukin-6. In conclusion,Helicobacter pylori infection results in a local increase in interleukins-1β and-6 and interleukin-2 receptor associated with high-grade mucosal inflammation. Interleukin-1β seems to favor anti-Helicobacter pylori antibody production, and mucosal levels are enhanced mainly in patients infected with cytotoxicHelicobacter pylori strains. Springer-Verlag, 1996 Helicobacter pylori nationallicence Interleukin-1β nationallicence Interleukin-6 nationallicence Interleukin-2 soluble receptor nationallicence CagA nationallicence Basso D. Dipartimento di Medicina di Laboratorio, Laboratorio Centrale, Via Giustiniani 2, 1-35128, Padua, Italy aut Scrigner M. Dipartimento di Medicina di Laboratorio, Laboratorio Centrale, Via Giustiniani 2, 1-35128, Padua, Italy aut Toma A. Dipartimento di Medicina di Laboratorio, Laboratorio Centrale, Via Giustiniani 2, 1-35128, Padua, Italy aut Navaglia F. Dipartimento di Medicina di Laboratorio, Laboratorio Centrale, Via Giustiniani 2, 1-35128, Padua, Italy aut Di Mario F. Cattedra di Gastroenterologica, Universita' degli Studi di Padova, Padua, Italy aut Rugge M. Cattedra di Istochimica & Immunoistochimica Patologica, Universita degli Studi di Padova, Padua, Italy aut Plebani M. Dipartimento di Medicina di Laboratorio, Laboratorio Centrale, Via Giustiniani 2, 1-35128, Padua, Italy aut International Journal of Clinical and Laboratory Research Springer-Verlag 26/3(1996-09-01), 207-210 0940-5437 26:3<207 1996 26 599 https://doi.org/10.1007/BF02592984 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02592984 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Basso D. Dipartimento di Medicina di Laboratorio, Laboratorio Centrale, Via Giustiniani 2, 1-35128, Padua, Italy aut NATIONALLICENCE 700 1- Scrigner M. Dipartimento di Medicina di Laboratorio, Laboratorio Centrale, Via Giustiniani 2, 1-35128, Padua, Italy aut NATIONALLICENCE 700 1- Toma A. Dipartimento di Medicina di Laboratorio, Laboratorio Centrale, Via Giustiniani 2, 1-35128, Padua, Italy aut NATIONALLICENCE 700 1- Navaglia F. Dipartimento di Medicina di Laboratorio, Laboratorio Centrale, Via Giustiniani 2, 1-35128, Padua, Italy aut NATIONALLICENCE 700 1- Di Mario F. Cattedra di Gastroenterologica, Universita' degli Studi di Padova, Padua, Italy aut NATIONALLICENCE 700 1- Rugge M. Cattedra di Istochimica & Immunoistochimica Patologica, Universita degli Studi di Padova, Padua, Italy aut NATIONALLICENCE 700 1- Plebani M. Dipartimento di Medicina di Laboratorio, Laboratorio Centrale, Via Giustiniani 2, 1-35128, Padua, Italy aut NATIONALLICENCE 773 0- International Journal of Clinical and Laboratory Research Springer-Verlag 26/3(1996-09-01), 207-210 0940-5437 26:3<207 1996 26 599 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer