caa a22 4500 477054412 CHVBK 20180405111344.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF02592979 doi (NATIONALLICENCE)springer-10.1007/BF02592979 Oxidized low-density lipoprotein and atherosclerosis [Elektronische Daten] [S. Devaraj, I. Jialal] Atherosclerosis is the leading cause of morbidity and mortality in western society. The most important risk factors for atherosclerosis include smoking, hypertension, dyslipidemia, diabetes and a family history of premature atherosclerosis. Several studies indicate that an increased plasma low density lipoprotein (LDL) cholesterol constitutes a major risk factor for atherosclerosis. Many data support a proatherogenic role for oxidized LDL and its in vivo existence. The oxidative susceptibility of LDL is increased with established cardiovascular risk factors, such as diabetes, smoking and dyslipidemia. Supplementation with antioxidants such as ascorbate and alpha-tocopherol can decrease LDL oxidation as well as cardiovascular mortality and thus shows promise in the prevention of atherosclerosis. Springer-Verlag, 1996 Low density lipoprotein nationallicence Atherosclerosis nationallicence Lipid peroxidation nationallicence Alpha-tocopherol nationallicence Ascorbate nationallicence Devaraj S. Center for Human Nutrition, University of Texas Southwestern Medical Center, 75235-9052, Dallas, TX, USA aut Jialal I. Department of Internal Medicine, University of Texas Southwestern Medical Center, 75235-9052, Dallas, TX, USA aut International Journal of Clinical and Laboratory Research Springer-Verlag 26/3(1996-09-01), 178-184 0940-5437 26:3<178 1996 26 599 https://doi.org/10.1007/BF02592979 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02592979 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Devaraj S. Center for Human Nutrition, University of Texas Southwestern Medical Center, 75235-9052, Dallas, TX, USA aut NATIONALLICENCE 700 1- Jialal I. Department of Internal Medicine, University of Texas Southwestern Medical Center, 75235-9052, Dallas, TX, USA aut NATIONALLICENCE 773 0- International Journal of Clinical and Laboratory Research Springer-Verlag 26/3(1996-09-01), 178-184 0940-5437 26:3<178 1996 26 599 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer