caa a22 4500 477054595 CHVBK 20180405111344.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/BF02602957 doi (NATIONALLICENCE)springer-10.1007/BF02602957 Serum copper/zinc superoxide dismutase levels in patients with rheumatoid arthritis [Elektronische Daten] [I. Mazzetti, B. Grigolo, R. Borzì, R. Meliconi, A. Facchini] Rheumatoid arthritis is characterized by a chronic hypertrophic synovitis leading to destruction of connective tissue and functional damage of cartilage and bone structures. Reactive oxygen species play an important role in tissue injury in this disease. To clarify the role of the cellular antioxidant system in the protection against oxygen free radicals, we examined the levels of copper/zinc superoxide dismutase in the sera of patients with rheumatoid arthritis. We used an enzyme-linked immunosorbent assaywhich determines the concentration of copper/zinc superoxide dismutase indepedently from its enzymatic activity. We found that patients with rheumatoid arthritis have higher serum copper/zinc superoxide dismutase levels than control subjects. Copper/zinc superoxide dismutase also correlated positively with serum levels of both neopterin and rheumatoid factor, sensitive markers for disease activity in rheumatoid arthritis. These results support the hypothesis that the increased amount of copper/zinc superoxide dismutase is probably inadequate to exert an effective antioxidant protection but can result in a pro-inflammatory, pathogenic effect enhancing tissue damage. Furthermore, copper/zinc superoxide dismutase might be used as a marker of inflammatory activity in rheumatoid arthritis. Springer-Verlag, 1996 Reactive oxygen species nationallicence Copper/zinc superoxide dismutase nationallicence Rheumatoid arthritis nationallicence Mazzetti I. Laboratorio di Immunologia e Genetica, Istituto di Ricerca Codivilla Putti, Istituti Ortopedici Rizzoli, Via di Barbiano 1/10, 1-40136, Bologna, Italy aut Grigolo B. Laboratorio di Immunologia e Genetica, Istituto di Ricerca Codivilla Putti, Istituti Ortopedici Rizzoli, Via di Barbiano 1/10, 1-40136, Bologna, Italy aut Borzì R. Laboratorio di Immunologia e Genetica, Istituto di Ricerca Codivilla Putti, Istituti Ortopedici Rizzoli, Via di Barbiano 1/10, 1-40136, Bologna, Italy aut Meliconi R. Dipartimento di Medicina Interna, Cardioangiologia, Epatologia, Universita degli Studi di Bologna, Bologna, Italy aut Facchini A. Laboratorio di Immunologia e Genetica, Istituto di Ricerca Codivilla Putti, Istituti Ortopedici Rizzoli, Via di Barbiano 1/10, 1-40136, Bologna, Italy aut International Journal of Clinical and Laboratory Research Springer-Verlag 26/4(1996-12-01), 245-249 0940-5437 26:4<245 1996 26 599 https://doi.org/10.1007/BF02602957 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02602957 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mazzetti I. Laboratorio di Immunologia e Genetica, Istituto di Ricerca Codivilla Putti, Istituti Ortopedici Rizzoli, Via di Barbiano 1/10, 1-40136, Bologna, Italy aut NATIONALLICENCE 700 1- Grigolo B. Laboratorio di Immunologia e Genetica, Istituto di Ricerca Codivilla Putti, Istituti Ortopedici Rizzoli, Via di Barbiano 1/10, 1-40136, Bologna, Italy aut NATIONALLICENCE 700 1- Borzì R. Laboratorio di Immunologia e Genetica, Istituto di Ricerca Codivilla Putti, Istituti Ortopedici Rizzoli, Via di Barbiano 1/10, 1-40136, Bologna, Italy aut NATIONALLICENCE 700 1- Meliconi R. Dipartimento di Medicina Interna, Cardioangiologia, Epatologia, Universita degli Studi di Bologna, Bologna, Italy aut NATIONALLICENCE 700 1- Facchini A. Laboratorio di Immunologia e Genetica, Istituto di Ricerca Codivilla Putti, Istituti Ortopedici Rizzoli, Via di Barbiano 1/10, 1-40136, Bologna, Italy aut NATIONALLICENCE 773 0- International Journal of Clinical and Laboratory Research Springer-Verlag 26/4(1996-12-01), 245-249 0940-5437 26:4<245 1996 26 599 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer