caa a22 4500 477054633 CHVBK 20180405111344.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/BF02602952 doi (NATIONALLICENCE)springer-10.1007/BF02602952 The role of chemokines in inflammation [Elektronische Daten] [P. Proost, A. Wuyts, J. Van Damme] Chemokines, together with adhesion molecules, cytokines, and proteases, are essential for the directional migration of leukocytes during normal and inflammatory processes. Interleukin-8 and monocyte chemotactic protein-1 are the best-characterized members of the C-X-C and C-C chemokine subfamilies, respectively. However, more than 20 human chemokines have been identified but are only partially characterized at the biological level. Chemokines are involved in chemotaxis of monocytes, lymphocytes, neutrophils, eosinophils, basophils, natural killer cells, dendritic cells, and endothelial cells. This review describes the chemokine subfamilies, the chemokine producer and target cells, their receptors, singal transduction mechanisms, and the role of chemokines during physiological and pathological conditions. More and more evidence points to a role for chemokines in chemotaxis-related phenomena, such as the expression of adhesion molecules, the secretion of proteinases, inhibition of apoptosis, hematopoiesis, and angiogenesis. Chemokines are also involved in diseases such as cancer (tumor regression and tumor metastasis), autoimmune diseases, and bacterial or viral infection. Springer-Verlag, 1996 Chemotaxis nationallicence Interleukin-8 nationallicence Leukocyte migration nationallicence Chemotactic cytokine nationallicence Proost P. Laboratory of Molecular Immunology, Rega Institute, K.U. Leuven, Minderbroedersstraat 10, B-3000, Leuven, Belgium aut Wuyts A. Laboratory of Molecular Immunology, Rega Institute, K.U. Leuven, Minderbroedersstraat 10, B-3000, Leuven, Belgium aut Van Damme J. Laboratory of Molecular Immunology, Rega Institute, K.U. Leuven, Minderbroedersstraat 10, B-3000, Leuven, Belgium aut International Journal of Clinical and Laboratory Research Springer-Verlag 26/4(1996-12-01), 211-223 0940-5437 26:4<211 1996 26 599 https://doi.org/10.1007/BF02602952 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02602952 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Proost P. Laboratory of Molecular Immunology, Rega Institute, K.U. Leuven, Minderbroedersstraat 10, B-3000, Leuven, Belgium aut NATIONALLICENCE 700 1- Wuyts A. Laboratory of Molecular Immunology, Rega Institute, K.U. Leuven, Minderbroedersstraat 10, B-3000, Leuven, Belgium aut NATIONALLICENCE 700 1- Van Damme J. Laboratory of Molecular Immunology, Rega Institute, K.U. Leuven, Minderbroedersstraat 10, B-3000, Leuven, Belgium aut NATIONALLICENCE 773 0- International Journal of Clinical and Laboratory Research Springer-Verlag 26/4(1996-12-01), 211-223 0940-5437 26:4<211 1996 26 599 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer