caa a22 4500 477054730 CHVBK 20180405111345.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/BF02592351 doi (NATIONALLICENCE)springer-10.1007/BF02592351 Preanalytical factors and the measurement of cytokines in human subjects [Elektronische Daten] [B. Dugué, E. Leppänen, R. Gräsbeck] Cytokines are widely measured in research. However, cytokine analyses are influenced by a myriad of factors. For instance, a delay in the separation of plasma from cells may lead to a 50% decrease in the concentration of tumor necrosis factor in plasma. Another example is the secretion of interleukin-1β in women which can be twice as high during the follicular phase as in the luteal phase. The factors influencing the outcome of these tests can be divided into in vivo preanalytical factors (e.g., aging chronobiological rhythms, diet, etc), in vitro preanalytical factors (e.g., specimen collection, equipment, transport, storage, etc), and analytical factors. To improve the value of the cytokine tests, factors strongly influencing the results have to be controlled. This can be done by using standardized assays and specimen collection procedures. In general, sufficient attention is not given to the preanalytical factors, especially in the measurement of cytokines. This article reviews the preanalytical factors which may influence the outcome of these tests in human subjects. Springer-Verlag, 1992 Cytokine measurement nationallicence Preanalytical factors nationallicence Dugué B. Minerva Foundation Institute for Medical Research, Tukholmankatu 2, FIN-00250, Helsinki, Finland aut Leppänen E. Minerva Foundation Institute for Medical Research, Tukholmankatu 2, FIN-00250, Helsinki, Finland aut Gräsbeck R. Minerva Foundation Institute for Medical Research, Tukholmankatu 2, FIN-00250, Helsinki, Finland aut International Journal of Clinical and Laboratory Research Springer-Verlag 26/2(1996-07-01), 99-105 0940-5437 26:2<99 1996 26 599 https://doi.org/10.1007/BF02592351 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02592351 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dugué B. Minerva Foundation Institute for Medical Research, Tukholmankatu 2, FIN-00250, Helsinki, Finland aut NATIONALLICENCE 700 1- Leppänen E. Minerva Foundation Institute for Medical Research, Tukholmankatu 2, FIN-00250, Helsinki, Finland aut NATIONALLICENCE 700 1- Gräsbeck R. Minerva Foundation Institute for Medical Research, Tukholmankatu 2, FIN-00250, Helsinki, Finland aut NATIONALLICENCE 773 0- International Journal of Clinical and Laboratory Research Springer-Verlag 26/2(1996-07-01), 99-105 0940-5437 26:2<99 1996 26 599 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer