caa a22 4500 477054889 CHVBK 20180405111345.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/BF02592349 doi (NATIONALLICENCE)springer-10.1007/BF02592349 Chemokines: a superfamily of chemotactic cytokines [Elektronische Daten] [S. Sozzani, M. Locati, P. Allavena, J. Van Damme, A. Mantovani] Chemokines are a bipartite family of chemotactic proteins that bear the structural hallmark of four cysteine residues, the first two of which are in tandem. The spectrum of action of chemokines encompasses a large number of leukocyte populations, including monocytes, granulocytes, lymphocytes, NK and dendritic cells. Although the spectrum of action of chemokines largely overlaps, clear differences are still present. Chemokines play an important role in the recruitment of leukocytes at the site of inflammation, allergic reaction and tumors. Available information on receptor usage by MCP-1 and related chemokines and signal transduction pathways is reviewed. The better understanding of signaling mechanisms will provide a new basis for the development of therapeutic strategies. Springer-Verlag, 1996 Chemokines nationallicence Chemotaxis nationallicence Pathology nationallicence Signal transduction nationallicence Sozzani S. Istituto di Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut Locati M. Istituto di Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut Allavena P. Istituto di Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut Van Damme J. Rega Institute, Leuven, Belgium aut Mantovani A. Istituto di Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut International Journal of Clinical and Laboratory Research Springer-Verlag 26/2(1996-07-01), 69-82 0940-5437 26:2<69 1996 26 599 https://doi.org/10.1007/BF02592349 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02592349 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sozzani S. Istituto di Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut NATIONALLICENCE 700 1- Locati M. Istituto di Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut NATIONALLICENCE 700 1- Allavena P. Istituto di Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut NATIONALLICENCE 700 1- Van Damme J. Rega Institute, Leuven, Belgium aut NATIONALLICENCE 700 1- Mantovani A. Istituto di Ricerche Farmacologiche "Mario Negri”, Via Eritrea 62, I-20157, Milan, Italy aut NATIONALLICENCE 773 0- International Journal of Clinical and Laboratory Research Springer-Verlag 26/2(1996-07-01), 69-82 0940-5437 26:2<69 1996 26 599 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer