caa a22 4500 477055850 CHVBK 20180405111346.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/s002280050208 doi (NATIONALLICENCE)springer-10.1007/s002280050208 Effects of heat exposure in a Finnish sauna on the pharmacokinetics and metabolism of midazolam [Elektronische Daten] [J. Vanakoski, J. J. Idänpään-Heikkilä, K. T. Olkkola, T. Seppälä] Objective: The effect of short-term heat exposure in a Finnish sauna on hepatic first-pass metabolism and the capacity to metabolize midazolam were studied in a crossover trial. Midazolam oral (15 mg) and intravenous (0.05 mg ⋅ kg−1) was given to 6 healthy young male volunteers, in random order, during a control session and a sauna bathing session (temperature 85-100° C, relative humidity 25-30%). Blood samples for the determination of plasma midazolam and α-hydroxy midazolam concentrations were taken for 6 h after drug administration. Results: After oral administration, the bioavailability and clearance of midazolam were not affected by sauna bathing, nor was there a significant difference in α-hydroxy midazolam plasma concentration or the α-hydroxy midazolam/midazolam AUC-ratio between the sessions. Midazolam Cmax was increased and its t1/2β was prolonged during the sauna session, but the clinical relevance of the findings appears to be modest. The pharmacokinetics of intravenous midazolam were not affected by sauna bathing. Conclusions: Short-term heat exposure may not affect the first-pass metabolism or hepatic capacity to metabolize midazolam. Springer-Verlag Berlin Heidelberg, 1996 Key words Midazolam nationallicence Sauna nationallicence metabolism nationallicence pharmacokinetics nationallicence heat nationallicence pharmacodynamics nationallicence Vanakoski J. Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, P.O. Box 8 (Siltavuorenpenger 10), FIN-00014, Finland, FI aut Idänpään-Heikkilä J. J. Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, P.O. Box 8 (Siltavuorenpenger 10), FIN-00014, Finland, FI aut Olkkola K. T. Department of Anaesthesia, University of Helsinki, Finland, FI aut Seppälä T. National Public Health Institute, Laboratory of Pharmacology and Toxicology, Helsinki, Finland, FI aut https://doi.org/10.1007/s002280050208 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s002280050208 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vanakoski J. Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, P.O. Box 8 (Siltavuorenpenger 10), FIN-00014, Finland, FI aut NATIONALLICENCE 700 1- Idänpään-Heikkilä J. J. Institute of Biomedicine, Department of Pharmacology and Toxicology, University of Helsinki, P.O. Box 8 (Siltavuorenpenger 10), FIN-00014, Finland, FI aut NATIONALLICENCE 700 1- Olkkola K. T. Department of Anaesthesia, University of Helsinki, Finland, FI aut NATIONALLICENCE 700 1- Seppälä T. National Public Health Institute, Laboratory of Pharmacology and Toxicology, Helsinki, Finland, FI aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer